YAP

[Scientific Reports] The Hippo pathway regulates the proliferation of cancer cells, pluripotent stem cells, and epithelial cells through a cell–cell contact-dependent manner, however, it is unclear if cell density-dependent cell proliferation is a consistent feature in cardiac myocytes. Scientists used cultured human iPSC-derived cardiac myocytes as a model system to investigate this concept.

[NPJ Regenerative Medicine] Researchers found that cerebrospinal fluid pulsation stress—cyclic pulsation stress—could promote the osteogenic and angiogenic abilities of rat MSCs, thereby promoting tissue-engineered laminae’s bone and blood vessel formation.

[Journal of Hepatology] Scientists investigated the functional contribution of Yes-associated protein and/or transcriptional co-activator with PDZ-binding motif (TAZ) during c-MYC induced liver tumor development.

[Acta Pharmacologica Sinica] Researchers investigated the effects of pantoprazole (PPZ), a proton pump inhibitor, against liver fibrosis in a bile duct ligation rat model, human hepatic stellate cell (HSC) line LX-2 and mouse primary HSCs, and explored the potential mechanisms underlying the effects of PPZ in vitro and in vivo.

[Molecular Cell] Researchers found that Neurofibromin 2 (NF2) facilitated innate immunity by regulating YAP/TAZ-mediated TBK1 inhibition. Patient-derived individual mutations in the FERM domain of NF2 converted NF2 into a potent suppressor of cGAS-STING signaling.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] By manipulating ROCK pathway, scientists demonstrated that stretch-induced Yap/Taz activation promoted alveolar differentiation towards alveolar epithelial type 1 phenotype via ROCK activity.