YAP

[Signal Transduction and Targeted Therapy] Scientists concisely introduce the physicochemical properties of hydrogels and their fabrication approaches.

[Journal of the American Heart Association] The conversion of fibroblasts into induced cardiomyocytes may regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Scientists explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.

[Science Signaling] Scientists studied the role of YAP/TAZ signaling in endothelial cells (ECs) in tumor angiogenesis and found that the expression of YAP/TAZ and downstream target genes in ECs correlated with tumor vascularization in human colorectal carcinomas and skin melanoma.

[Hepatology Communications] Treatment effects on tumor-initiating cells were estimated by sphere-forming capacity in vitro, tumorigenicity in vivo, and flow cytometry.

[Journal of Cell Science] Researchers assessed a potential role of TAZ on theSmad7/β-catenin complex in muscle cells. They documented functional interactions between Smad7, TAZ and β-catenin in myogenic cells.

[Cell Death & Disease] Scientists uncovered a conserved Yki/YAP-Src42A/SRC positive feedback loop promoting tumor cell migration and provided SRC as a potential therapeutic target for YAP-driven metastatic tumors.