Zika

[Virology Journal] Researchers evaluated the replication kinetics of Zika virus and the related encephalitic flavivirus West Nile strain Kunjin virus in early-term placental cell lines.

[Cancer Research] To investigate recurrently dysregulated genes in glioblastoma, scientists interrogated allele-specific expression, the difference in expression between two alleles of a gene, in glioblastoma stem cells derived from 43 patients.

[Proceedings of the National Academy of Sciences of the United States of America] Zika virus infection of trophoblasts caused endoplasmic reticulum stress, which made them decidual NK targets by down-regulating HLA-C/G, natural killer inhibitory receptor ligands that helped maintain tolerance of the semiallogeneic fetus.

[Molecular Therapy-Oncolytics] The receptor tyrosine kinase AXL has been identified as an entry receptor for Zika virus (ZIKV) in a cell type-specific manner. Interestingly, AXL was frequently overexpressed in glioblastoma (GBM) patients. The authors demonstrated that ZIKV entry into GBM cells in vitro was mediated by the AXL receptor.

[Nature Reviews Microbiology] The authors consider the extent to which recent global changes have increased the risk of infectious disease outbreaks, even as improved sanitation and access to health care have resulted in considerable progress worldwide.

[Science Signaling] Scientists found that SERINC3 and SERINC5 exhibited additional antiviral activities by enhancing the expression of genes encoding type I interferons and nuclear factor κB signaling.