ABT-199

[Acta Biomaterialia] Researchers compared the anti-leukemic ability of pure ABT-199 and PEG-ABT-199 in vitro and in vivo.

[Biochemical Pharmacology] Investigators proposed a mechanism by which hydroquinone induced the malignant progression of chronic myeloid leukemia cells.

[Cell Death & Disease] Scientists focused on the BCL-2 specific inhibitor venetoclax and its effects following short-term and long-term BCL-2 blockade on T cell subsets.

[Inflammatory Bowel Diseases] Scientists evaluated the proapoptotic and antifibrotic efficacy of several classes of BH-3 mimetics in two in vitro fibrogenesis models. The candidate molecule, ABT-263, was advanced to a 3D human intestinal organoid model.

[Journal of Cancer Research and Clinical Oncology] CSCs had low EGFR expression and, conversely, overexpressed the anti-apoptotic Bcl-2 protein, which is involved in resistance to apoptosis and the invasion/migration capacities of tumor cells.

[Molecular Cancer Research] Researchers showed that, dasatinib in melanoma stimulated its proper mechanism of resistance, independently of MAPK and PI3K/AKT pathway reactivation commonly associated to secondary c-Kit mutations, but through CRTC3/MITF/Bcl-2 pathway activation at clinically relevant doses.