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acinar cells

Abnormal Exocrine–Endocrine Cell Cross-Talk Promotes β-Cell Dysfunction and Loss in MODY8

[Nature Metabolism] Researchers reported the transfer of carboxyl ester lipase proteins from acinar cells to β-cells as a form of cross-talk between exocrine and endocrine cells.

Exposure to Perfluorooctanoic Acid Leads to Promotion of Pancreatic Cancer

[Carcinogenesis] Researchers demonstrated that perfluorooctanoic acid induced oxidative stress and focal ductal hyperplasia in the mouse pancreas.

Intra-Pancreatic Fat Deposition: Bringing Hidden Fat to the Fore

[Nature Reviews Gastroenterology & Hepatology] Weight loss-induced decrease of intra-pancreatic fat is tightly associated with remission of type 2 diabetes mellitus and its re-deposition with recurrence of the disease.

Differential Activation of CaCa2+ Influx Channels Modulate Stem Cell Potency, Their Proliferation/Viability and Tissue Regeneration

[NPJ Regenerative Medicine] Investigators show that store-dependent Ca2+ entry was essential for modulating the function of bone marrow-derived MSCs.

Acinar Cell Clonal Expansion in Pancreas Homeostasis and Carcinogenesis

[Nature] Using lineage tracing from the endogenous telomerase reverse transcriptase (Tert) locus, scientists identified a rare TERT-positive subpopulation of pancreatic acinar cells dispersed throughout the exocrine compartment.

Loss of the Ciliary Protein Chibby1 in Mice Leads to Exocrine Pancreatic Degeneration and Pancreatitis

[Scientific Reports] Scientists reported that Chibby(Cby)1-knockout (KO) mice developed severe exocrine pancreatic atrophy with dilated ducts during early postnatal development. A significant reduction in the number and length of cilia was observed in Cby1-KO pancreta.

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