As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Researchers separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs could improve lipopolysaccharide-induced lung and distal organ injury; and explored the underlying mechanisms.
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
The authors investigated whether phillygenin could inhibit inflammation and apoptosis of pulmonary epithelial cells by activating peroxisome proliferator‑activated receptor γ (PPARγ) signaling.
[Molecular Medicine Reports]
[zotpress userid=” items=’PDVWCBVV’ style=’apa’ cite=’yes’]
Scientists reported that a chromatin modulator protein arginine N-methyltransferase 4/coactivator-associated arginine methyltransferase 1 was elevated in human lung tissues with pneumonia and in experimental lung injury models.
[Cell Death & Disease]
[zotpress userid=” items=’3ASDTUFE’ style=’apa’ cite=’yes’]
Scientists systematically review preclinical studies, explored the effectiveness of mesenchyal stem cells (MSCs) in the treatment of bleomycin-induced pulmonary fibrosis and analyze the potential mechanism, combined with clinical trials of current MSCs for idiopathic pulmonary fibrosis and COVID-19, so as to provide support for clinical research and transformation of MSCs.
[Stem Cell Research & Therapy]
[zotpress userid=” items=’HEQPFFAC’ style=’apa’ cite=’yes’]
Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.
[Acta Pharmacologica Sinica]
[zotpress userid=” items=’B8WZEPM2′ style=’apa’ cite=’yes’]
Scientists review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, leading to secretion of the pleiotropic IL-1 family cytokines and pyroptosis.
[Nature Reviews Immunology]
[zotpress userid=’6445218′ items=’E9R5QKNK’ style=’apa’ cite=’yes’]
A549 lung epithelial cells transfected with Klotho cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
[zotpress userid=” items=’I6KXZR6Z’ style=’apa’ cite=’yes’]
Scientists elucidated the role of plasma extracellular vesicles in delivering miR-210-3p in sepsis-induced acute lung injury.
[Experimental & Molecular Medicine]
[zotpress userid=” items=’ABQTUUFH’ style=’apa’ cite=’yes’]
Investigators discuss the possible use of natural killer (NK) cells cells as a therapeutic agent in view of preventing immunological harms of SARS-CoV-2 and the current challenges in advocating NK cell therapy for the same.
[zotpress userid=” items=’A7P4BBVE’ style=’apa’ cite=’yes’]
Researchers investigated the involvement of zinc finger protein 36 (ZFP36) and cAMP‐response element-binding protein binding protein (CREBBP) on ischemia–reperfusion (I/R)-induced lung injury in vivo and in vitro.
[Cell Death & Disease]
[zotpress userid=” items=’E8CV8IDM’ style=’apa’ cite=’yes’]