Scientists focused on the important role of macrophage polarization in cecal ligation puncture-mediated acute lung injury and determined the ability of saquinavir to maintain M2 over M1 phenotype partially through the inhibition of matrix metalloproteinase-9.
[Cell Death & Disease]
Tong, Y., Yu, Z., Chen, Z., Zhang, R., Ding, X., Yang, X., Niu, X., Li, M., Zhang, L., Billiar, T. R., Pitt, B. R., & Li, Q. (2021). The HIV protease inhibitor Saquinavir attenuates sepsis-induced acute lung injury and promotes M2 macrophage polarization via targeting matrix metalloproteinase-9. Cell Death & Disease, 12(1), 1–14. https://doi.org/10.1038/s41419-020-03320-0 Cite
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