Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
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Chicken Bone Marrow Mesenchymal Stem Cells Improve Lung and Distal Organ Injury

Researchers separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs could improve lipopolysaccharide-induced lung and distal organ injury; and explored the underlying mechanisms.
[Scientific Reports]
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Phillygenin Inhibits the Inflammation and Apoptosis of Pulmonary Epithelial Cells by Activating PPARγ Signaling via Downregulation of MMP8

The authors investigated whether phillygenin could inhibit inflammation and apoptosis of pulmonary epithelial cells by activating peroxisome proliferator‑activated receptor γ (PPARγ) signaling.
[Molecular Medicine Reports]
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Endotoxin Stabilizes Protein Arginine Methyltransferase 4 (PRMT4) Protein Triggering Death of Lung Epithelia

Scientists reported that a chromatin modulator protein arginine N-methyltransferase 4/coactivator-associated arginine methyltransferase 1 was elevated in human lung tissues with pneumonia and in experimental lung injury models.
[Cell Death & Disease]
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Effectivity of Mesenchymal Stem Cells for Bleomycin-Induced Pulmonary Fibrosis: A Systematic Review and Implication for Clinical Application

Scientists systematically review preclinical studies, explored the effectiveness of mesenchyal stem cells (MSCs) in the treatment of bleomycin-induced pulmonary fibrosis and analyze the potential mechanism, combined with clinical trials of current MSCs for idiopathic pulmonary fibrosis and COVID-19, so as to provide support for clinical research and transformation of MSCs.
[Stem Cell Research & Therapy]
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Ethyl Ferulate Protects against Lipopolysaccharide-Induced Acute Lung Injury by Activating AMPK/Nrf2 Signaling Pathway

Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.
[Acta Pharmacologica Sinica]
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Inflammasome Activation at the Crux of Severe COVID-19

Scientists review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, leading to secretion of the pleiotropic IL-1 family cytokines and pyroptosis.
[Nature Reviews Immunology]
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Constitutive Transgenic Alpha-Klotho Overexpression Enhances Resilience to and Recovery from Murine Acute Lung Injury

A549 lung epithelial cells transfected with Klotho cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Plasma Extracellular Vesicle Delivery of miR-210-3p by Targeting ATG7 to Promote Sepsis-Induced Acute Lung Injury by Regulating Autophagy and Activating Inflammation

Scientists elucidated the role of plasma extracellular vesicles in delivering miR-210-3p in sepsis-induced acute lung injury.
[Experimental & Molecular Medicine]
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Bracing NK Cell Based Therapy to Relegate Pulmonary Inflammation in COVID-19

Investigators discuss the possible use of natural killer (NK) cells cells as a therapeutic agent in view of preventing immunological harms of SARS-CoV-2 and the current challenges in advocating NK cell therapy for the same.
[Heliyon]
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ZFP36 Protects Lungs from Intestinal I/R-Induced Injury and Fibrosis through the CREBBP/p53/p21/Bax Pathway

Researchers investigated the involvement of zinc finger protein 36 (ZFP36) and cAMP‐response element-binding protein binding protein (CREBBP) on ischemia–reperfusion (I/R)-induced lung injury in vivo and in vitro.
[Cell Death & Disease]
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