Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome

Human and mouse model bronchoalveolar lavage fluid samples were analyzed for the presence and activity of cathepsin S and its endogenous inhibitors.
[American Journal of Respiratory and Critical Care Medicine]
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Exosomes from Adipose-Derived Mesenchymal Stem Cells Alleviate Sepsis-Induced Lung Injury in Mice by Inhibiting the Secretion of IL-27 in Macrophages

The authors investigated the mechanism of exosomes from adipose-derived MSCs in sepsis-induced acute lung injury.
[Cell Death Discovery]
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SARS-CoV-2-Triggered Mast Cell Rapid Degranulation Induces Alveolar Epithelial Inflammation and Lung Injury

Scientists showed that SARS-CoV-2-triggered mast cells degranulation initiated alveolar epithelial inflammation and lung injury.
[Signal Transduction and Targeted Therapy]
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Extracorporeal Membrane Oxygenation in Children Receiving Hematopoietic Cell Transplantation and Immune Effector Cell Therapy: An International and Multidisciplinary Consensus Statement

The authors provide a clinical decision support tool for pediatric hematologists, oncologists, and critical care physicians during the difficult decision-making process of extracorporeal membrane oxygenation candidacy and management.
[Lancet Child & Adolescent Health]
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ACE2-Like Carboxypeptidase B38-CAP Protects from SARS-CoV-2-Induced Lung Injury

Researchers showed that B38-CAP, an ACE2-like enzyme, was protective against SARS-CoV-2-induced lung injury.
[Nature Communications]
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Lung Inflammation and Damage in Nonclinical Acute Lung Injury: Implications for COVID-19

Researchers identified a role for MSC-extracellular vesicles in immune modulation and cellular salvage in a model of SARS-CoV-2 induced acute lung injury using pulmonary epithelial cells and exposure to cytokines or the SARS-CoV-2 receptor binding domain.
[PLoS One]
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RvD1 Accelerates the Resolution of Inflammation by Promoting Apoptosis of the Recruited Macrophages via the ALX/FasL-FasR/Caspase-3 Signaling Pathway

Mice were administered Resolvin D1 via the tail vein 3 and 4 days after stimulation with lipopolysaccharide.
[Cell Death Discovery]
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Vitti Labs Announces FDA Approval of IND Application for Phase II Clinical Trial of Combination Mesenchymal Stem Cell and Exosome Treatment of Novel Corona Virus Infection (COVID-19)

Vitti Labs announced that the US FDA has approved its Investigational New Drug (IND) application to conduct Phase II Clinical Trials using a combination of umbilical cord mesenchymal stem cell and umbilical cord mesenchymal stem cell exosomes for the treatment of Acute Respiratory Distress Syndrome associated with COVID-19.
[Vitti Labs (PR Newswire, Inc.)]
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Molecular Programs of Fibrotic Change in Aging Human Lung

Researchers profiled distal lung samples from healthy human donors across the lifespan and revealed the transcriptional and structural features of fibrosis and associated functional impairment in normal lung aging.
[Nature Communications]
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Nrf2 Attenuates Ferroptosis-Mediated IIR-ALI by Modulating TERT and SLC7A11

Researchers found that telomerase reverse transcriptase (TERT) was significantly reduced in lung tissue of Nrf2−/− mice in the model of intestinal ischemia/reperfusion-induced acute lung injury (IIR-ALI)
[Cell Death & Disease]
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LncRNA NEAT1 Aggravates Lipopolysaccharide-Induced Acute Lung Injury by Regulating the miR-98-5p/TLR4 Axis

Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). NEAT1 knockdown efficiently attenuated LPS-induced ALI and reduced LPS-induced elevation of cytokines both in vitro and in vivo
[Journal of Biochemical and Molecular Toxicology]
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