acute lung injury

[Scientific Reports] Researchers separated chicken bone marrow-derived mesenchymal stem cells (BM-MSCs); investigated whether BM-MSCs could improve lipopolysaccharide-induced lung and distal organ injury; and explored the underlying mechanisms.

[Molecular Medicine Reports] The authors investigated whether phillygenin could inhibit inflammation and apoptosis of pulmonary epithelial cells by activating peroxisome proliferator‑activated receptor γ (PPARγ) signaling.

[Cell Death & Disease] Scientists reported that a chromatin modulator protein arginine N-methyltransferase 4/coactivator-associated arginine methyltransferase 1 was elevated in human lung tissues with pneumonia and in experimental lung injury models.

[Stem Cell Research & Therapy] Scientists systematically review preclinical studies, explored the effectiveness of mesenchyal stem cells (MSCs) in the treatment of bleomycin-induced pulmonary fibrosis and analyze the potential mechanism, combined with clinical trials of current MSCs for idiopathic pulmonary fibrosis and COVID-19, so as to provide support for clinical research and transformation of MSCs.

[Acta Pharmacologica Sinica] Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.

[Nature Reviews Immunology] Scientists review evidence that SARS-CoV-2 directly or indirectly activates inflammasomes, leading to secretion of the pleiotropic IL-1 family cytokines and pyroptosis.