acute myeloid leukemia

[Biochemical Pharmacology] Investigators proposed a mechanism by which hydroquinone induced the malignant progression of chronic myeloid leukemia cells.

[Clinical Cancer Research] The combination of crenolanib and sorafenib was tolerable with antileukemic activities and rare emergence of FLT3-TKD mutations, which warrants further investigation.

[Journal of Hematology & Oncology] The role of wild-type isocitrate dehydrogenase-2 (IDH2) in AML cell survival and proliferation was tested using genetic knockdown and pharmacological inhibition in AML cells and animal models.

[Cancer Research] The authors established cells with acquired resistance to the allosteric SHP2 inhibitor SHP099 from two FLT3-ITD-positive AML cell lines.

[Oryzon Genomics, S.A.] Oryzon Genomics, S.A. announced that it has received notification from the US FDA that its Investigational New Drug application (IND) for iadademstat is now approved to initiate a Phase Ib clinical trial in patients with relapsed/refractory AML harboring a FMS-like tyrosine kinase mutation (FLT3mut+ ).

[Cell Reports] Investigators established that identification of the comprehensive miRNA targetome within primary cells enabled discovery of genes and molecular networks underpinning stemness properties of normal and leukemic cells.