Human PSCs were subject to directed differentiation through a paraxial mesoderm progenitor state that generates brown adipocytes (BAs) at high efficiency. Molecular analysis identified potential regulatory networks for BA development, giving insight into development along this lineage.
[Cell Stem Cell]
6630899 P483A48G items 1 apa default asc 1
Fetal resistin levels were measured in cord blood from pregnancies with and without maternal diabetes. Secretion of resistin from cord blood mononuclear cells was measured.
6445212 G6UAYRUI items 1 apa default asc 1
Investigators demonstrated that Celastrol promotes osteoblast differentiation and prevents adipocyte differentiation in bone marrow mesenchymal stem cells in vitro.
1254621 5X5LDGCE items 1 apa default asc 1
PIK3CA (H1047R) Activating Mutation and Enhanced Activity of PI3K/AKT Pathway were Detected in Macrodactylous Adipose-Derived Stem Cells (Mac-ADSCs).
[Cell Death & Disease]
1254621 VIIQ6UPL items 1 apa default asc 1
The authors performed cellular, kinematic, physiological, and anatomical analyses, either in vitro or in vivo, to comprehensively evaluate the safety and efficacy associated with subarachnoid transplantation of human umbilical cord mesenchymal stem cells in rats with subacute incomplete spinal cord injury.
[Experimental Cell Research]
1254621 K57MAXHB items 1 apa default asc 1
C57BL/6 mice were randomly divided into two groups: a control group and a hindlimb suspension group. After four weeks of hindlimb suspension, scientists found that this simulated microgravity condition increased the percentage of monocytes and macrophages and decreased the percentage of B lymphocytes and mature red cells in bone marrow.
[Cell Biology International]
1254621 JQMMSZ86 items 1 apa default asc 1
Researchers showed that pretreatment with sarsasapogenin significantly inhibited acute adipose tissue inflammatory responses in LPS-treated mice.
[Acta Pharmacologica Sinica]
This review describes the current understanding of the origin, different types, anatomical location, and genetics of adipose tissue as well as discussing the properties of adipose-derived stem cells and their promising applications for tissue engineering, scarring, and wound healing.
[Journal of Clinical Medicine]
6606345 IXRQHKDU items 1 apa default asc 1
Using a novel in-vitro 3D human adipocyte/pre-adipocyte spheroid model, researchers investigated whether adipocytes and their precursors secreted factors that affected human dermal fibroblast behavior.
6630899 S4GI9EMH items 1 apa default asc 1
Mechanistically, Angpt2 activated integrin α5β1 signaling in the endothelium and triggered fatty acid transport via CD36 and FATP3 into subcutaneous adipose tissue. Genetic or pharmacological inhibition of the endothelial integrin α5β1 recapitulated adipocyte-specific Angpt2 knockout phenotypes.