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adipocytes

Aged Bone Matrix-Derived Extracellular Vesicles as a Messenger for Calcification Paradox

[Nature Communications] The authors showed that extracellular vesicles derived from aged bone matrix during bone resorption favored bone marrow MSC adipogenesis rather than osteogenesis and augmented calcification of vascular smooth muscle cells.

The RNA-Binding Protein Musashi2 Governs Osteoblast-Adipocyte Lineage Commitment by Suppressing PPARγ Signaling

[Bone Research] Researchers found that the RNA-binding protein Musashi2 regulated bone marrow MSCs (BMSCs) lineage commitment and found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs.

BioRestorative Therapies Announces Research Collaboration with Professor Tore Bengtsson to Evaluate Heat Production of its ThermoStem® Program

[BioRestorative Therapies, Inc. (Globe Newswire, Inc.)] BioRestorative Therapies, Inc., a clinical stage company focused on stem cell-based therapies, announced that it has entered into a research collaboration agreement with Dr. Tore Bengtsson, Professor of the Department of Molecular Biosciences, at the Wenner-Gren Institute, at Stockholm University.

Obesity-Induced Galectin-9 Is a Therapeutic Target in B Cell Acute Lymphoblastic Leukemia

[Nature Communications] Investigators showed that the adipocyte secretome upregulated the surface expression of Galectin-9 on human B-acute lymphoblastic leukemia cells which promoted chemoresistance.

Antimicrobial Production by Perifollicular Dermal Preadipocytes Is Essential to the Pathophysiology of Acne

[Science Translational Medicine] Scientists investigated the potential role of adipogenesis by dermal fibroblasts in acne and performed single-cell RNA sequencing on human acne lesions and mouse skin challenged by Cutibacterium acnes.

ADRB3 Induces Mobilization and Inhibits Differentiation of Both Breast Cancer Cells and Myeloid-Derived Suppressor Cells

[Cell Death & Disease] ADRB3 promoted metastasis by inducing mobilization and inhibiting differentiation of both breast cancer cells and myeloid-derived suppressor cells.

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