Circular RNA AFF4 Modulates Osteogenic Differentiation in BM-MSCs by Activating SMAD1/5 Pathway through miR-135a-5p/FNDC5/Irisin Axis

Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease]
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Statins Reduce Castration-Induced Bone Marrow Adiposity and Prostate Cancer Progression in Bone

Investigators showed that the cholesterol-lowering drugs statins decreased castration-induced bone marrow adiposity in the tumor microenvironment and reduced prostate cancer progression in bone.
[Oncogene]
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Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer

The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
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PRL-1 Overexpressed Placenta-Derived Mesenchymal Stem Cells Suppress Adipogenesis in Graves’ Ophthalmopathy through SREBP2/HMGCR Pathway

Investigators constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.
[Stem Cell Research & Therapy]
Park, M., Kim, J. Y., Kang, J. M., Lee, H. J., Banga, J. P., Kim, G. J., & Lew, H. (2021). PRL-1 overexpressed placenta-derived mesenchymal stem cells suppress adipogenesis in Graves’ ophthalmopathy through SREBP2/HMGCR pathway. Stem Cell Research & Therapy, 12(1), 304. https://doi.org/10.1186/s13287-021-02337-2 Cite
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PP2A in LepR+ Mesenchymal Stem Cells Contributes to Embryonic and Postnatal Endochondral Ossification through Runx2 Dephosphorylation

The authors fate mapped the leptin receptor-expressing (LepR+) MSCs in different embryonic and adult extremities using Lepr-cre; tdTomato mice and investigated the underling mechanism using Lepr-cre; Ppp2r1afl/fl mice.
[Communications Biology]
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A Human Multi-Cellular Model Shows How Platelets Drive Production of Diseased Extracellular Matrix and Tissue Invasion

Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.
[iScience]
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Orphan GPR116 Mediates the Insulin Sensitizing Effects of the Hepatokine FNDC4 in Adipose Tissue

Scientists found that the liver primarily controlled the circulating levels of soluble FNDC4 (sFNDC4) and lowering of the hepatokine FNDC4 led to prediabetes in mice.
[Nature Communications]
Georgiadi, A., Lopez-Salazar, V., Merahbi, R. E.-, Karikari, R. A., Ma, X., Mourão, A., Klepac, K., Bühler, L., Alfaro, A. J., Kaczmarek, I., Linford, A., Bosma, M., Shilkova, O., Ritvos, O., Nakamura, N., Hirose, S., Lassi, M., Teperino, R., Machado, J., … Herzig, S. (2021). Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nature Communications, 12(1), 2999. https://doi.org/10.1038/s41467-021-22579-1 Cite
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Wnt/ß-Catenin-Mediated p53 Suppression Is Indispensable for Osteogenesis of Mesenchymal Progenitor Cells

Using conditional lineage-tracing mice, scientists demonstrated that chondrocytes gave rise to a sizable fraction of mesenchymal progenitor cells, which served as progenitors of chondrocyte-derived osteoblasts.
[Cell Death & Disease]
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UCP1 Governs Liver Extracellular Succinate and Inflammatory Pathogenesis

Researchers identified an endocrine pathway regulated by Uncoupling protein 1 (UCP1) that antagonizes liver inflammation and pathology, independent of effects on obesity.
[Nature Metabolism]
Mills, E. L., Harmon, C., Jedrychowski, M. P., Xiao, H., Garrity, R., Tran, N. V., Bradshaw, G. A., Fu, A., Szpyt, J., Reddy, A., Prendeville, H., Danial, N. N., Gygi, S. P., Lynch, L., & Chouchani, E. T. (2021). UCP1 governs liver extracellular succinate and inflammatory pathogenesis. Nature Metabolism, 1–14. https://doi.org/10.1038/s42255-021-00389-5 Cite
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Endocrine Role of Bone in the Regulation of Energy Metabolism

The authors summarize the regulatory effect of bone and bone-derived factors on energy metabolism and discuss directions for future research.
[Bone Research]
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The Effects of Locomotion on Bone Marrow Mesenchymal Stem Cell Fate: Insight Into Mechanical Regulation and Bone Formation

Scientists summarize the regulatory effects of locomotion/mechanical loading on bone marrow MSCs activities.
[Cell and Bioscience]
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