Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity

The authors present current knowledge on adipose stem and progenitor cells (ASPCs), their population structure, hierarchy, fat depot-specific nature, function, and regulatory mechanisms, and discuss not only the similarities, but also the differences between mouse and human ASPC biology.
[Trends in Cell Biology]
Ferrero, R., Rainer, P., & Deplancke, B. (2020). Toward a Consensus View of Mammalian Adipocyte Stem and Progenitor Cell Heterogeneity. Trends in Cell Biology, 0(0). https://doi.org/10.1016/j.tcb.2020.09.007 Cite
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Soluble Factors Released by Dedifferentiated Fat Cells Reduce the Functional Activity of iPS Cell‐Derived Cardiomyocytes

Scientists evaluated the effects of soluble factor interactions in indirect cocultures of dedifferentiated fat cells and induced pluripotent stem cell‐derived cardiomyocytes.
[Cell Biology International]
Watanabe, H., Kanemaru, K., Hagikura, K., Matsumoto, T., Ayusawa, M., & Morioka, I. (n.d.). Soluble factors released by dedifferentiated fat cells reduce the functional activity of iPS cell-derived cardiomyocytes. Cell Biology International, n/a(n/a). https://doi.org/10.1002/cbin.11487 Cite
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Exosome-Mediated Metabolic Reprogramming: The Emerging Role in Tumor Microenvironment Remodeling and Its Influence on Cancer Progression

The authors present the role of exosomes in the tumor microenvironment and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.
[Signal Transduction and Targeted Therapy]
Yang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020). Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00359-5 Cite
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Leptin Modulates Pancreatic β-Cell Membrane Potential through Src Kinase-Mediated Phosphorylation of NMDA Receptors

Scientists report that leptin augments NMDA subtype of glutamate receptors function via Src kinase-mediated phosphorylation of the GluN2A subunit.
[Journal of Biological Chemistry]
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Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction

The authors address the effect of malignant cells, adjuvant therapies and patient-specific factors that may influence the success of regenerative strategies using adipose derived stromal cells (ADSCs) for post cancer tissue regeneration.
[Stem Cell Reviews and Reports]
Challapalli, R. S., Dwyer, R. M., McInerney, N., Kerin, M. J., & Lowery, A. J. (2020). Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10038-1 Cite
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Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion

Researchers demonstrated that expression of the transcriptional coregulator GPS2 in white adipose tissue was correlated with insulin secretion rate in humans.
[Cell Reports]
Drareni, K., Ballaire, R., Alzaid, F., Goncalves, A., Chollet, C., Barilla, S., Nguewa, J.-L., Dias, K., Lemoine, S., Riveline, J.-P., Roussel, R., Dalmas, E., Velho, G., Treuter, E., Gautier, J.-F., & Venteclef, N. (2020). Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion. Cell Reports, 32(11). https://doi.org/10.1016/j.celrep.2020.108141 Cite
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Selective Inhibition of CBP/p300 HAT by A-485 Results in Suppression of Lipogenesis and Hepatic Gluconeogenesis

In primary mouse hepatocytes, A-485 abolished cAMP-elicited mRNA expressions of key gluconeogenic enzymes and promoted FOXO1 protein degradation via increasing its ubiquitination.
[Cell Death & Disease]
Zhou, F., Liu, Q., Zhang, L., Zhu, Q., Wang, S., Zhu, K., Deng, R., Liu, Y., Yuan, G., Wang, X., & Zhou, L. (2020). Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis. Cell Death & Disease, 11(9), 1–12. https://doi.org/10.1038/s41419-020-02960-6 Cite
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Upregulation of CPT1A Is Essential for the Tumor-Promoting Effect of Adipocytes in Colon Cancer

Scientists demonstrated that carnitine palmitoyltransferase I (CPT1A), a key enzyme controlling fatty acid oxidation, was upregulated in colon cancer cells upon exposure to adipocytes or fatty acids.
[Cell Death & Disease]
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MicroRNA-3148 Acts As Molecular Switch Promoting Malignant Transformation and Adipocytic Differentiation of Immortalized Human Bone Marrow Stromal Cells via Direct Targeting of the SMAD2/TGFβ Pathway

Scientists investigated the role of miR-3148 in regulating human stromal mesenchymal stem cell differentiation and transformation.
[Cell Death Discovery]
Vishnubalaji, R., Elango, R., Manikandan, M., Siyal, A.-A., Ali, D., Al-Rikabi, A., Hamam, D., Hamam, R., Benabdelkamel, H., Masood, A., Alanazi, I. O., Alfadda, A. A., Alfayez, M., Aldahmash, A., Kassem, M., & Alajez, N. M. (2020). MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway. Cell Death Discovery, 6(1), 1–16. https://doi.org/10.1038/s41420-020-00312-z Cite
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Biochanin a Induces a Brown-Fat Phenotype via Improvement of Mitochondrial Biogenesis and Activation of AMPK Signaling in Murine C3H10T1/2 Mesenchymal Stem Cells

Scientists investigated the effect of Biochanin A, an O‐methylated isoflavone on the brown‐fat phenotype formation and on the associated thermogenic program including mitochondrial biogenesis and lipolysis in C3H10T1/2 MSCs.
[Phytotherapy Research]
Rahman, M. S., Imran, K. M., Hossain, M., Lee, T.-J., & Kim, Y.-S. (n.d.). Biochanin A induces a brown-fat phenotype via improvement of mitochondrial biogenesis and activation of AMPK signaling in murine C3H10T1/2 mesenchymal stem cells. Phytotherapy Research, n/a(n/a). https://doi.org/10.1002/ptr.6845 Cite
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TGF-β Is Insufficient to Induce Adipocyte State Loss without Concurrent PPARγ Downregulation

Scientists found that the intracellular TGF-β signaling in adipocytes was inhibited by the transcriptional factor PPARγ, specifically by its ubiquitously expressed isoform PPARγ1. However, TGF-β led to adipocyte state loss when it was present simultaneously with another stimulus.
[Scientific Reports]
Taylor, B., Shah, A., & Bielczyk-Maczyńska, E. (2020). TGF-β is insufficient to induce adipocyte state loss without concurrent PPARγ downregulation. Scientific Reports, 10(1), 14084. https://doi.org/10.1038/s41598-020-71100-z Cite
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