The authors present current knowledge on adipose stem and progenitor cells (ASPCs), their population structure, hierarchy, fat depot-specific nature, function, and regulatory mechanisms, and discuss not only the similarities, but also the differences between mouse and human ASPC biology.
[Trends in Cell Biology]
Scientists evaluated the effects of soluble factor interactions in indirect cocultures of dedifferentiated fat cells and induced pluripotent stem cell‐derived cardiomyocytes.
[Cell Biology International]
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The authors present the role of exosomes in the tumor microenvironment and the underlying mechanism of how exosomes exacerbate tumor development through metabolic reprogramming.
[Signal Transduction and Targeted Therapy]
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Yang, E., Wang, X., Gong, Z., Yu, M., Wu, H., & Zhang, D. (2020). Exosome-mediated metabolic reprogramming: the emerging role in tumor microenvironment remodeling and its influence on cancer progression. Signal Transduction and Targeted Therapy, 5(1), 1–13. https://doi.org/10.1038/s41392-020-00359-5 Cite
Scientists report that leptin augments NMDA subtype of glutamate receptors function via Src kinase-mediated phosphorylation of the GluN2A subunit.
[Journal of Biological Chemistry]
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The authors address the effect of malignant cells, adjuvant therapies and patient-specific factors that may influence the success of regenerative strategies using adipose derived stromal cells (ADSCs) for post cancer tissue regeneration.
[Stem Cell Reviews and Reports]
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Challapalli, R. S., Dwyer, R. M., McInerney, N., Kerin, M. J., & Lowery, A. J. (2020). Effect of Breast Cancer and Adjuvant Therapy on Adipose-Derived Stromal Cells: Implications for the Role of ADSCs in Regenerative Strategies for Breast Reconstruction. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10038-1 Cite
Researchers demonstrated that expression of the transcriptional coregulator GPS2 in white adipose tissue was correlated with insulin secretion rate in humans.
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Drareni, K., Ballaire, R., Alzaid, F., Goncalves, A., Chollet, C., Barilla, S., Nguewa, J.-L., Dias, K., Lemoine, S., Riveline, J.-P., Roussel, R., Dalmas, E., Velho, G., Treuter, E., Gautier, J.-F., & Venteclef, N. (2020). Adipocyte Reprogramming by the Transcriptional Coregulator GPS2 Impacts Beta Cell Insulin Secretion. Cell Reports, 32(11). https://doi.org/10.1016/j.celrep.2020.108141 Cite
In primary mouse hepatocytes, A-485 abolished cAMP-elicited mRNA expressions of key gluconeogenic enzymes and promoted FOXO1 protein degradation via increasing its ubiquitination.
[Cell Death & Disease]
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Zhou, F., Liu, Q., Zhang, L., Zhu, Q., Wang, S., Zhu, K., Deng, R., Liu, Y., Yuan, G., Wang, X., & Zhou, L. (2020). Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis. Cell Death & Disease, 11(9), 1–12. https://doi.org/10.1038/s41419-020-02960-6 Cite
Scientists demonstrated that carnitine palmitoyltransferase I (CPT1A), a key enzyme controlling fatty acid oxidation, was upregulated in colon cancer cells upon exposure to adipocytes or fatty acids.
[Cell Death & Disease]
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Scientists investigated the role of miR-3148 in regulating human stromal mesenchymal stem cell differentiation and transformation.
[Cell Death Discovery]
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Vishnubalaji, R., Elango, R., Manikandan, M., Siyal, A.-A., Ali, D., Al-Rikabi, A., Hamam, D., Hamam, R., Benabdelkamel, H., Masood, A., Alanazi, I. O., Alfadda, A. A., Alfayez, M., Aldahmash, A., Kassem, M., & Alajez, N. M. (2020). MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway. Cell Death Discovery, 6(1), 1–16. https://doi.org/10.1038/s41420-020-00312-z Cite
Scientists investigated the effect of Biochanin A, an O‐methylated isoflavone on the brown‐fat phenotype formation and on the associated thermogenic program including mitochondrial biogenesis and lipolysis in C3H10T1/2 MSCs.
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Rahman, M. S., Imran, K. M., Hossain, M., Lee, T.-J., & Kim, Y.-S. (n.d.). Biochanin A induces a brown-fat phenotype via improvement of mitochondrial biogenesis and activation of AMPK signaling in murine C3H10T1/2 mesenchymal stem cells. Phytotherapy Research, n/a(n/a). https://doi.org/10.1002/ptr.6845 Cite
Scientists found that the intracellular TGF-β signaling in adipocytes was inhibited by the transcriptional factor PPARγ, specifically by its ubiquitously expressed isoform PPARγ1. However, TGF-β led to adipocyte state loss when it was present simultaneously with another stimulus.