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adipocytes

Insight into the Role of Dermal White Adipose Tissue Loss in Dermal Fibrosis

[Journal of Cellular Physiology] The authors indicate that the adipocytes-to-myofibroblasts transition in dermal white adipose tissue reflects the direct contribution to the dermal fibrosis formation

Hop2 Interacts with the Transcription Factor CEBPα and Suppresses Adipocyte Differentiation

[Journal of Biological Chemistry] These in vitro data suggest that Hop2 inhibited adipogenesis by suppressing CEBP-mediated transactivation. Consistent with a negative role for Hop2 in adipogenesis, ablation of Hop2 in mice led to increased body weight, adipose volume, adipocyte size, and adipogenic marker gene expression.

Circulating Cytokines Present in Multiple Myeloma Patients Inhibit the Osteoblastic Differentiation of Adipose Stem Cells

[Leukemia] Scientists examined the effects of plasma from myeloma patients at diagnosis and in complete remission and from healthy donors on the osteoblastic differentiation of healthy donor-derived adipose-dervied MSCs.

Pcpe2, a Novel Extracellular Matrix Protein, Regulates Adipocyte SR-BI–Mediated High-Density Lipoprotein Uptake

[Arteriosclerosis Thrombosis and Vascular Biology] The authors investigated the role of adipocyte procollagen C-endopeptidase enhancer 2 (Pcpe2) in scavenger receptor class BI (SR-BI)–mediated high-density lipoprotein cholesterol uptake and contributions to adipose lipid storage.

KARATE: PKA-Induced KRAS4B-RHOA-mTORC2 Supercomplex Phosphorylates AKT in Insulin Signaling and Glucose Homeostasis

[Molecular Cell] By investigating insulin receptor signaling in human cells and biochemical reconstitution, scientists found that insulin induced the activation of mTORC2 toward AKT by assembling a supercomplex with KRAS4B and RHOA GTPases, termed KARATE (KRAS4B-RHOA-mTORC2 Ensemble).

FGF-2–Dependent Signaling Activated in Aged Human Skeletal Muscle Promotes Intramuscular Adipogenesis

[Proceedings of the National Academy of Sciences of the United States of America] Using multiple screening assays upstream and downstream of miR-29a signaling, investigators located the secreted protein and adipogenic inhibitor SPARC to an fibroblast growth factor-2 (FGF-2) signaling pathway that was conserved between skeletal muscle cells from mice and humans and that was activated in skeletal muscle of aged mice and humans.

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