adipose-derived stem cells

[Scientific Reports] Investigators reported a new approach that enables the formation of self-assembled 3D spheroids of adipose-derived stem cells and murine hepatocytes via reconstituted collagen fibers.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators evaluated the efficacy of intraarticular injections of amnion membrane hydrogels with and without adipose-derived stem cells in reducing inflammation and cartilage degeneration in a collagenase-induced osteoarthritis rat model.

[NPJ Regenerative Medicine] Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists engineered a SASC system which mimicked the paracrine effect of the stem cell secretome and provided tailorability of the composition for targeted tissue regeneration.

[Stanford Health] Sanford Health announced a stem cell trial expanding the use of adult-adipose derived stem cells in the use of osteoarthritis across five joints. The clinical trial, called the ENDURE trial, is the first of its kind study.

[Hypertension Research] Hypoxia increased α1-AR and vascular endothelial growth factor (VEGF) mRNA levels in adipose-derived stem cells. Norepinephrine further increased VEGF mRNA expression under hypoxia; this effect was abolished by doxazosin.