METTL3 Promotes Adriamycin Resistance in MCF-7 Breast Cancer Cells by Accelerating Pri-microRNA-221-3p Maturation in a m6A-Dependent Manner

Scientists identified the methyltransferase-like 3/microRNA-221-3p/homeodomain-interacting protein kinase 2/Che-1 (METTL3/miR-221-3p/HIPK2/Che-1) axis as a novel signaling event that may be responsible for resistance of breast cancer cells to adriamycin.
[Experimental and Molecular Medicine]
Pan, X., Hong, X., Li, S., Meng, P., & Xiao, F. (2021). METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-00510-w Cite
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Proteomic Profiling and Genome-Wide Mapping of O-GlcNAc Chromatin-Associated Proteins Reveal an O-GlcNAc-Regulated Genotoxic Stress Response

Comprehensive data was obtained by a chemical reporter-based method to survey O-GlcNAc function in human breast cancer cells stimulated with the genotoxic agent adriamycin.
[Nature Communications]
Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response | Nature Communications. (n.d.). Retrieved November 19, 2020, from https://www.nature.com/articles/s41467-020-19579-y Cite
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