Scientists identified the methyltransferase-like 3/microRNA-221-3p/homeodomain-interacting protein kinase 2/Che-1 (METTL3/miR-221-3p/HIPK2/Che-1) axis as a novel signaling event that may be responsible for resistance of breast cancer cells to adriamycin.
Pan, X., Hong, X., Li, S., Meng, P., & Xiao, F. (2021). METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Experimental & Molecular Medicine, 1–12. https://doi.org/10.1038/s12276-020-00510-wCite