AIDS

[AIDS] Researchers studied CD4/CD8 over time to determine whether it predicted risk for select comorbidities and mortality among aging people with HIV with viral suppression.

[Journal of Medical Virology] The authors examined distribution of the well-characterized +874 T/A IFN-γ and -509C/T TGF-β1 single nucleotide polymorphisms in Thai people living with HIV.

[Signal Transduction and Targeted Therapy] Investigators provide a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and discuss their role in human disease.

[Microbial Pathogenesis] A brief account of the polymorphism in the APOBEC3G, TRIM5α, and BST2 genes are explored among different populations along with the interaction of APOBEC3G with Vif protein.

[Nature Reviews Immunology] Scientists discuss novel latency-reversing agents targeting DCs as well as DC-based strategies to enhance the clearance of infected cells by CD8+ T cells and strategies to improve the killing activity of natural killer cells.

[Molecular Neurodegeneration] Investigators determined whether HIV-1 infection caused Alzheimer’s Disease-like pathologies in an HIV/AIDS humanized mouse model, and whether the CCR5 antagonist maraviroc altered HIV-induced pathologies.