AIDS

[ScienceInsider] Opening a new chapter in the treatment of COVID-19—one borrowed from successfully tackling the AIDS virus—the drug behemoth Pfizer reported upbeat results for a 5-day pill regimen to treat early infections with SARS-CoV-2.

[Molecular Therapy] Scientists revealed that MSC-derived exosomes resided specifically in the injured kidney and delivered miRNA-34c-5p to reduce cellular activation and renal interstitial fibrosis by inhibiting core fucosylation.

[Enochian BioSciences, Inc.] Enochian BioSciences, Inc. announced the completion of a Pre-Investigational New Drug process for ENOB-HB-01, a novel approach to potentially eliminate HBV-infected liver cells with an innovative “Hijack RNA” strategy that co-opts the virus’ machinery to induce the death of infected cells rather than reproducing and causing more infection and liver disease.

[Mycopathologia] Scientists review clinical manifestations, radiological findings and treatment options according to the clinical form, as well as different diagnosis tools and new laboratory tests that have been recently developed and validated and are becoming widely available.

[Human Genetics] Investigators discuss the advantages and limitations of conventional models of the human auditory system, describe the generation and characteristics of PSC-derived inner ear organoids, and discuss several strategies and recent attempts to model hereditary deafness in vitro.

[Journal of Infectious Diseases] Despite the phenotypic and transcriptional similarities between cord blood and adult macrophages, cord blood cells were prone to viral replication when infected with HIV-1.