A Medium Composition Containing Normal Resting Glucose That Supports Differentiation of Primary Human Airway Cells

Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.
[Scientific Reports]
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Human Airway Lineages Derived from Pluripotent Stem Cells Reveal the Epithelial Responses to SARS-CoV-2 Infection

Investigators presented a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that was permissive to SARS-CoV-2 infection.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.
[Journal of Clinical Investigation]
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Overexpression of miR-375 Reverses the Effects of Dexamethasone on the Viability, Migration, Invasion and Apoptosis of Human Airway Epithelial Cells by Targeting DUSP6

The altered expression of microRNAs has been found in asthma. However, the detailed mechanisms responsible for the effects of miR‑375 on Dex‑induced airway epithelial cell dysfunction remain elusive. Researchers elucidated these mechanisms.
[International Journal of Molecular Medicine]
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ITGB4 Deficiency Induces Mucus Hypersecretion by Upregulating MUC5AC in RSV-Infected Airway Epithelial Cells

Researchers found that decreased expression of ITGB4 was negatively correlated with the level of MUC5AC in childhood airway epithelial cells following respiratory syncytial virus (RSV) infection.
[International Journal of Biological Sciences]
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Meteorin-β/Meteorin Like/IL-41 Attenuates Airway Inflammation in House Dust Mite-Induced Allergic Asthma

Increased Metrnβ effectively blocked the development of airway hyperreactivity and decreased inflammatory cell airway infiltration and type 2 cytokine production, which was associated with downregulated dendritic-mediated adaptive immune responses.
[Cellular & Molecular Immunology]
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The Sodium/Glucose Cotransporters as Potential Therapeutic Targets for Cystic Fibrosis Lung Diseases Revealed by Human Lung Organoid Swelling Assay

Scientists derived human proximal lung organoids from patient-derived pluripotent stem cells carrying disease-causing cystic fibrosis transmembrane conductance regulator mutations.
[Molecular Therapy-Methods & Clinical Development]
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Toxicity of Stainless and Mild Steel Particles Generated from Gas–Metal Arc Welding in Primary Human Small Airway Epithelial Cells

Scientists evaluated the toxicity of stainless and mild steel particles generated via gas–metal arc welding using primary human small airway epithelial cells and ToxTracker reporter murine stem cells, which tracked activation of six cancer-related pathways.
[Scientific Reports]
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Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.
[Molecular Medicine Reports]
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Electronic Cigarette Smoke Reduces Ribosomal Protein Gene Expression to Impair Protein Synthesis in Primary Human Airway Epithelial Cells

Researchers reported transcriptomic changes, including decreased expression of many ribosomal genes, in airway epithelial cells in response to e-cig exposure.
[Scientific Reports]
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Cells of the Human Respiratory Tract Support the Replication of Pathogenic Old World Orthohantavirus Puumala

Researchers analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus in vitro.
[Virology Journal]
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