Serum-Derived Exosomes from House Dust Mite-Sensitized Guinea Pigs Contribute to Inflammation in BEAS-2B Cells via the TLR4-NF-κB Pathway

The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.
[Molecular Medicine Reports]
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Electronic Cigarette Smoke Reduces Ribosomal Protein Gene Expression to Impair Protein Synthesis in Primary Human Airway Epithelial Cells

Researchers reported transcriptomic changes, including decreased expression of many ribosomal genes, in airway epithelial cells in response to e-cig exposure.
[Scientific Reports]
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Cells of the Human Respiratory Tract Support the Replication of Pathogenic Old World Orthohantavirus Puumala

Researchers analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus in vitro.
[Virology Journal]
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YAP Regulates Alveolar Epithelial Cell Differentiation and AGER via NFIB/KLF5/NKX2-1

Postnatal YAP activation increased epithelial cell proliferation, increased alveolar type-1 cell numbers, and caused indeterminate differentiation of subsets of alveolar cells expressing atypical genes normally restricted to airway epithelial cells.
[iScience]
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Disease Modeling Following Organoid-Based Expansion of Airway Epithelial Cells

Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns, and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells were 3D-expanded, whereas cells from BT were expanded in 3D and 2D.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
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Poly-L-Arginine Promotes Asthma Angiogenesis through Induction of FGFBP1 in Airway Epithelial Cells via Activation of the mTORC1-STAT3 Pathway

Scientists demonstrated that fibroblast growth factor-binding protein 1 was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine, a mimic of major basic protein.
[Cell Death & Disease]
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Somatic Cell Hemoglobin Modulates Nitrogen Oxide Metabolism in the Human Airway Epithelium

Primary human airway epithelial cells, cultured at air–liquid interface, were obtained by clinical airway brushings or from explanted lungs. Human airway Hb mRNA data were from publically available databases; or from RT-PCR.
[Scientific Reports]
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Pulmonary Fibrosis Distal Airway Epithelia Are Dynamically and Structurally Dysfunctional

Scientists demonstrated that healthy and idiopathic pulmonary fibrosis (IPF) airway epithelia were biophysically distinct, identifying pathologic activation of the ERBB-YAP axis as a specific and modifiable driver of prolongation of the unjammed-to-jammed transition in IPF epithelia.
[Nature Communications]
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Core-Shell Hydrogel Microfiber-Expanded Pluripotent Stem Cell-Derived Lung Progenitors Applicable to Lung Reconstruction In Vivo

The authors established an expansion system of hPSC-derived lung progenitors based on their 3D culture in core-shell hydrogel microfibers, that ensures the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II cells.
[Biomaterials]
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High-Throughput Human Primary Cell-Based Airway Model for Evaluating Influenza, Coronavirus, or Other Respiratory Viruses In Vitro

Scientists integrated human primary airway epithelial cells into a custom-engineered 96-device platform in which tissues were cultured in an array of microchannel-based culture chambers at an air–liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing.
[Scientific Reports]
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S100A9 in Adult Asthmatic Patients: A Biomarker for Neutrophilic Asthma

Researchers investigated the mechanism by which S100A9 was involved in neutrophil activation, neutrophil extracellular trap-induced airway inflammation, and macrophage polarization in neutrophilic asthma.
[Experimental & Molecular Medicine]
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