airway epithelial cells

[Immunology & Cell Biology] Researchers presented a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection.

[Thorax] Given that COPD often shares structural features with Birt-Hogg-Dubé syndrome, scientists investigated the link between COPD, cigarette smoke exposure and folliculin gene expression.

[Scientific Reports] The authors explored the anti-inflammatory effects and underlying molecular mechanism of povidone-iodine (PVP-I) on lipopolysaccharide-stimulated airway epithelial cells and investigated whether nasal instillation of PVP-I could suppress mucosal inflammation in non-eosinophilic chronic rhinosinusitis mice.

[Nature Communications] The authors reported that PF-332 exerted equipotent in vitro activity against the four SARS-CoV-2 variants of concerns and that it could completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators comprehensively analyzed the antiviral activity of all IFNα subtypes against SARS-CoV-2 to identify the underlying immune signatures and explore their therapeutic potential.

[Scientific Reports] Investigators expanded and differentiated human basal cells isolated from the nasal and conducting airway to a mature mucociliary epithelial cell layer at air–liquid interface using a medium formulation containing normal resting glucose levels.