The authors investigated whether serum exosomes played a pro‑inflammatory role in bronchial epithelial cells and explored the underlying molecular mechanisms.
[Molecular Medicine Reports]
[zotpress userid=” items=’TSEJIJ6D’ style=’apa’ cite=’yes’]
Researchers reported transcriptomic changes, including decreased expression of many ribosomal genes, in airway epithelial cells in response to e-cig exposure.
[zotpress userid=” items=’PCPCIB4D’ style=’apa’ cite=’yes’]
Researchers analyzed the permissiveness of primary endothelial cells of the human pulmonary microvasculature and of primary human epithelial cells derived from bronchi, bronchioles and alveoli for Old World orthohantavirus Puumala virus in vitro.
[zotpress userid=’6445218′ items=’W76YBYAW’ style=’apa’ cite=’yes’]
Postnatal YAP activation increased epithelial cell proliferation, increased alveolar type-1 cell numbers, and caused indeterminate differentiation of subsets of alveolar cells expressing atypical genes normally restricted to airway epithelial cells.
[zotpress userid=” items=’BEJTCJT9′ style=’apa’ cite=’yes’]
Airway epithelial cells were obtained from tracheal aspirates (TA) from preterm newborns, and from bronchoalveolar lavage (BAL) or bronchial tissue (BT) from adults. TA and BAL cells were 3D-expanded, whereas cells from BT were expanded in 3D and 2D.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]
[zotpress userid=” items=’GIMPPNR5′ style=’apa’ cite=’yes’]
Scientists demonstrated that fibroblast growth factor-binding protein 1 was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine, a mimic of major basic protein.
[Cell Death & Disease]
[zotpress userid=” items=’DK6XXUSZ’ style=’apa’ cite=’yes’]
Primary human airway epithelial cells, cultured at air–liquid interface, were obtained by clinical airway brushings or from explanted lungs. Human airway Hb mRNA data were from publically available databases; or from RT-PCR.
[zotpress userid=” items=’R9RU7KND’ style=’apa’ cite=’yes’]
Scientists demonstrated that healthy and idiopathic pulmonary fibrosis (IPF) airway epithelia were biophysically distinct, identifying pathologic activation of the ERBB-YAP axis as a specific and modifiable driver of prolongation of the unjammed-to-jammed transition in IPF epithelia.
[zotpress userid=” items=’KC6ZBD9E’ style=’apa’ cite=’yes’]
The authors established an expansion system of hPSC-derived lung progenitors based on their 3D culture in core-shell hydrogel microfibers, that ensures the maintenance of their bipotency for differentiation into alveolar and airway epithelial cells including alveolar type II cells.
[zotpress userid=” items=’7YDQTEIJ’ style=’apa’ cite=’yes’]
Scientists integrated human primary airway epithelial cells into a custom-engineered 96-device platform in which tissues were cultured in an array of microchannel-based culture chambers at an air–liquid interface, in a configuration compatible with high resolution in-situ imaging and real-time sensing.
[zotpress userid=” items=’RIPQXTJ8′ style=’apa’ cite=’yes’]
Researchers investigated the mechanism by which S100A9 was involved in neutrophil activation, neutrophil extracellular trap-induced airway inflammation, and macrophage polarization in neutrophilic asthma.
[Experimental & Molecular Medicine]
[zotpress userid=’6445218′ items=’CYIH8B69′ style=’apa’ cite=’yes’]