alveolar epithelial cells

[iScience] Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.

[Journal of Immunology] Using a mouse model of sepsis, scientists found that the long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) was highly expressed in mice during the late phase of sepsis.

[Signal Transduction and Targeted Therapy] Scientists showed that SARS-CoV-2-triggered mast cells degranulation initiated alveolar epithelial inflammation and lung injury.

[Chemico-Biological interactions] Researchers investigated the role of components of the Hippo signaling pathway for E-cadherin-mediated contact inhibition of proliferation in the lungs after air pollution exposure.

[Stem Cell Reports] Scientists established a novel in vitro pulmonary fibrosis model using alveolar organoids consisting of human pluripotent stem cell-derived alveolar epithelial cells and primary human lung fibroblasts.

[Cell Death & Disease] Researchers found that telomerase reverse transcriptase (TERT) was significantly reduced in lung tissue of Nrf2−/− mice in the model of intestinal ischemia/reperfusion-induced acute lung injury (IIR-ALI)