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alveolar epithelial cells

Gene Transfer of MRCKα Rescues Lipopolysaccharide-Induced Acute Lung Injury by Restoring Alveolar Capillary Barrier Function

[Scientific Reports] Researchers investigated whether electroporation-mediated gene transfer of MRCKα to the lungs can attenuate LPS-induced acute lung injury in vivo.

Lung Epithelial and Endothelial Damage, Loss of Tissue Repair, Inhibition of Fibrinolysis, and Cellular Senescence in Fatal COVID-19

[Science Translational Medicine] Lung autopsy samples from 18 patients with fatal COVID-19, with symptom onset-to-death times ranging from 3 to 47 days, and antemortem plasma samples from 6 of these cases were evaluated using deep sequencing of SARS-CoV-2 RNA, multiplex plasma protein measurements, and pulmonary gene expression and imaging analyses.

In Vitro Genotoxicity of Dibutyl Phthalate on A549 Lung Cells at Air-Liquid Interface in Exposure Concentrations Relevant at Workplaces

[Environmental and Molecular Mutagenesis] While in vitro studies were often based on submerged exposures, this study aimed to expose A549 alveolar epithelial cells at the air-liquid interface (ALI) to unravel the genotoxic and oxidative stress-inducing potential of dibutyl phthalate (DBP) with concentrations relevant at occupational settings.

Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

[Evidence-Based Complementary and Alternative Medicine] As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.

A cGAS-Dependent Response Links DNA Damage and Senescence in Alveolar Epithelial Cells: A Potential Drug Target in IPF

[American Journal of Physiology-Lung Cellular and Molecular Physiology] Scientists investigated the role of the DNA-sensing GMP-AMP synthase in idiopathic pulmonary fibrosis, with a focus on alveolar epithelial cell senescence.

Concomitant and Decoupled Effects of Cigarette Smoke and SCAL1 Upregulation on Oncogenic Phenotypes and ROS Detoxification in Lung Adenocarcinoma Cells

[Scientific Reports] A novel long noncoding RNA called smoke and cancer-associated lncRNA 1 was recently found upregulated in smoke-exposed adenocarcinomic alveolar epithelial cells.

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