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amyotrophic lateral sclerosis

iPSC-Based Disease Modeling and Drug Discovery in Cardinal Neurodegenerative Disorders

[Cell Stem Cell] The authors outline advances in iPSC modeling and therapeutic development for cardinal neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease.

Astrocytes Display Cell Autonomous and Diverse Early Reactive States in Familial Amyotrophic Lateral Sclerosis

[Brain] The authors revealed that reactive transformation can occur cell autonomously in human ALS astrocytes and with a striking degree of early molecular and functional heterogeneity when comparing different disease-causing mutations.

AI Therapeutics Announces Initiation of a Phase II Clinical Trial of AIT-101 for Treatment of ALS

[AI Therapeutics, Inc.] AI Therapeutics, Inc., a clinical-stage biopharmaceutical company developing novel therapeutics for rare diseases, announced the initiation of a Phase II study for a promising new approach to treat ALS.

Effects of Intracellular Calcium Accumulation on Proteins Encoded by the Major Genes Underlying Amyotrophic Lateral Sclerosis

[Scientific Reports] Researchers aimed to find a relationship between the proteins coded by the most relevant genes associated with amyotrophic lateral sclerosis and intracellular Ca2+ accumulation.

PharmaTher Announces FDA Approval of Investigational New Drug (IND) Application for Ketamine to Treat ALS

[PharmaTher Holdings Ltd.] PharmaTher Holdings Ltd. announced that the US FDA has accepted an investigator-initiated IND application to proceed with a Phase II clinical trial evaluating ketamine in the treatment of Amyotrophic Lateral Sclerosis (ALS).

Human Stem Cell Models of Neurodegeneration: From Basic Science of Amyotrophic Lateral Sclerosis to Clinical Translation

[Cell Stem Cell] The authors evaluate the status of modeling neurodegenerative diseases using iPSCs, including methods for deriving and using disease-relevant neuronal and glial lineages.

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