Vascular Stress Signaling in Hypertension

Investigators discuss common adaptive signaling mechanisms against these stresses including unfolded protein responses, antioxidant response element signaling, autophagy, mitophagy, and mitochondrial fission/fusion, signaling effector stimulator of interferon genes-mediated responses, and activation of pattern recognition receptors.
[Circulation Research]
Cicalese Stephanie M., da Silva Josiane Fernandes, Priviero Fernanda, Webb R. Clinton, Eguchi Satoru, & Tostes Rita C. (2021). Vascular Stress Signaling in Hypertension. Circulation Research, 128(7), 969–992. https://doi.org/10.1161/CIRCRESAHA.121.318053 Cite
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(E)-N-(2-(3, 5-Dimethoxystyryl) Phenyl) Furan-2-Carboxamide (BK3C231) Induces Cytoprotection in CCD18-Co Human Colon Fibroblast Cells through Nrf2/ARE Pathway Activation

The authors investigated the molecular mechanisms underlying BK3C231-induced cytoprotection and the involvement of the Nrf2/ARE pathway.
[Scientific Reports]
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Vitexin Protects Melanocytes from Oxidative Stress via Activating MAPK-Nrf2/ARE Pathway

The authors investigated the antioxidant effect of vitexin-activated mitogen-activated protein kinase-Nrf2/ARE axis in vitiligo.
[Immunopharmacology and Immunotoxicology]
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PTEN Status Determines Chemosensitivity to Proteasome Inhibition in Cholangiocarcinoma

Scientists determined that phosphate and tensin homology deleted on chromosome ten (PTEN) deficiency promoted protein synthesis and proteasome subunit expression and proteolytic activity, creating a dependency on the proteasome for cancer cell growth and survival.
[Science Translational Medicine]
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Oncogenic Function of TRIM2 in Pancreatic Cancer by Activating ROS-Related NRF2/ITGB7/FAK Axis

Researchers demonstrated that tripartite motif-containing 2 (TRIM2) was expressed in a high percentage of pancreatic tumors. High TRIM2 expression was negatively correlated with the outcome of pancreatic cancer. TRIM2 silencing significantly inhibited the proliferation, migration, invasion, and in vivo tumorigenicity of pancreatic cancer cells.
[Oncogene]
Sun, Q., Ye, Z., Qin, Y., Fan, G., Ji, S., Zhuo, Q., Xu, W., Liu, W., Hu, Q., Liu, M., Zhang, Z., Xu, X., & Yu, X. (2020). Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01452-3 Cite
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