antioxidant response element

[Circulation Research] Investigators discuss common adaptive signaling mechanisms against these stresses including unfolded protein responses, antioxidant response element signaling, autophagy, mitophagy, and mitochondrial fission/fusion, signaling effector stimulator of interferon genes-mediated responses, and activation of pattern recognition receptors.

[Scientific Reports] The authors investigated the molecular mechanisms underlying BK3C231-induced cytoprotection and the involvement of the Nrf2/ARE pathway.

[Immunopharmacology and Immunotoxicology] The authors investigated the antioxidant effect of vitexin-activated mitogen-activated protein kinase-Nrf2/ARE axis in vitiligo.

[Science Translational Medicine] Scientists determined that phosphate and tensin homology deleted on chromosome ten (PTEN) deficiency promoted protein synthesis and proteasome subunit expression and proteolytic activity, creating a dependency on the proteasome for cancer cell growth and survival.

[Oncogene] Researchers demonstrated that tripartite motif-containing 2 (TRIM2) was expressed in a high percentage of pancreatic tumors. High TRIM2 expression was negatively correlated with the outcome of pancreatic cancer. TRIM2 silencing significantly inhibited the proliferation, migration, invasion, and in vivo tumorigenicity of pancreatic cancer cells.