asthma

[Scientific Reports] Researchers hypothesized that the autophagy pathway was required for resolution of mucous metaplasia by eliminating excess non-secreted intracellular mucin granules.

[Scientific Reports] Scientists characterized the immune processes induced by the epithelium after urban particulate matter exposure in special regard to interactions with monocyte-derived dendritic cells and monocyte-derived macrophages in obstructive lung diseases.

[Journal of Immunology] Researchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported.

[Cell] Scientists showed that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide utilization from the metagenome, is associated with systemic inflammation and immune dysregulation early in life.

[Scientific Reports] Investigators analyzed gene expression response in in vitro differentiated bronchial epithelium exposed to cytokines and next infected with Human rhinoviruses 16.

[Journal of Translational Medicine] Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.