astrocytes

[Frontiers in Cell and Developmental Biology] Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that most striatal astrocyte-derived neurons were confined to the anterior medial striatum, did not express established striatal neuronal markers, and exhibited dendritic spines, which were atypical for striatal interneurons.

[Neuropsychopharmacology] Scientists investigated the mechanisms underlying the aberrant activation of microglia elicited by Meth in the adult mouse brain. They found that binge Meth exposure caused microgliosis and disrupted risk assessment behavior both of which required astrocyte-to-microglia crosstalk.

[Acta Pharmacologica Sinica] Researchers showed that CKLF1 was significantly up-regulated in cultured rat cortical neurons subjected to oxygen-glucose deprivation/reoxygenation (ODG/R) injury, but not in cultured rat microglia, astrocytes and oligodendrocytes.

[Nature Biomedical Engineering] Researchers used the model to track the infiltration of a number of candidate stem cells and to characterize the expression levels of genes associated with post-stroke pathologies.

[Molecular Psychiatry] To efficiently transform genetic associations into drug targets for Alzheimer’s disease, researchers employed an integrative analytical pipeline using proteomes in the brain and blood by systematically applying proteome-wide association study, Mendelian randomization and Bayesian colocalization.