astrocytes

[Molecular Psychiatry] Investigators utilized an isogenic human induced pluripotent stem cell (hiPSC)-based system to demonstrate that conversion of APOE3 to APOE2 greatly reduced the production of amyloid-beta peptides in hiPSC-derived neural cultures.

[Molecular Psychiatry] Scientists provide a brief overview of the role of astrocytes in regulating synaptic transmission and neuronal function, and discuss how cocaine influences these astrocyte-mediated mechanisms to induce persistent synaptic and circuit alterations that promote cocaine seeking and relapse.

[Science Advances] Investigators showed that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures.

[Nature] Scientists defined a critical period in a developing Drosophila motor circuit and identified astrocytes as essential for proper critical period termination.

[Cell Death & Disease] The authors report that C3G downregulation promoted the acquisition of a more mesenchymal phenotype that enhanced the migratory and invasive capacity of glioblastoma cells.

[npj Parkinsons Disease] In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.