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astrocytes

Activated Endothelial Cells Induce a Distinct Type of Astrocytic Reactivity

[Communications Biology] The authors showed that endothelial-induced astrocytes had upregulated expression of A1 astrocytic genes and exhibited a distinctive ECM remodeling profile.

Immune Responses in the Parkinsons’s Disease Brain

[Neurobiology of Disease] Current evidence points towards infiltrating monocytes as also playing a role in neuron death. Further characterization of the successive molecular changes in both the resident and peripheral immune cells invading the Parkinson's disease brain will provide targets for disease modification.

Excessive Release of Inorganic Phosphate by ALS/FTD Astrocytes Causes Non-Cell-Autonomous Toxicity to Motoneurons

[Neuron] Researchers reported that mouse and patient induced pluripotent stem cells-derived astrocytes with diverse ALS/frontotemporal dementia (FTD)-linked mutations (SOD1, TARDBP, and C9ORF72) displayed elevated levels of intracellular inorganic polyphosphate.

Localized Astrogenesis Regulates Gyrification of the Cerebral Cortex

[Developmental Neuroscience] The authors showed that localized astrogenesis played an important role in gyri formation in the gyrencephalic cerebral cortex.

Tissue-Engineered In Vitro Modeling of the Impact of Schwann Cells in Amyotrophic Lateral Sclerosis

[Biotechnology and Bioengineering] Scientists investigated whether Schwann cells could be involved in the disease pathogenesis, and developed a tissue-engineered 3D in vitro model that combined motor neurons cocultured with astrocytes.

Reactive Gliosis in Alzheimer’s Disease: A Crucial Role for Cognitive Impairment and Memory Loss

[Metabolic Brain Disease] The authors review the mechanisms by which a reactive gliosis can induce or contribute to the development and progression of Alzheimer’s disease.

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