The Current Landscape of Immunotherapy for Pediatric Brain Tumors

Investigators review recent advances and ongoing challenges in pediatric brain cancer immunotherapy, as well as considerations for efficient clinical translation of efficacious immunotherapies into pediatric settings.
[Nature Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells

Researchers interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-derived glioblastoma (GBM) stem cells (GSCs), differentiated GBM cells, and neural stem cells to identify master regulators of GSC stemness.
[Cancer Discovery]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

POLE2 Facilitates the Malignant Phenotypes of Glioblastoma through Promoting AURKA-Mediated Stabilization of FOXM1

The authors revealed crucial roles and a novel mechanism of poly ε-B subunit (POLE2) involved in glioblastoma (GBM) through Aurora kinase A (AURKA)-mediated stability of forkhead transcription factor (FOXM1) and may provide the theoretical basis of molecular therapy for GBM.
[Cell Death & Disease]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

NOXXON Provides Progress Update on the Expansion Arms of the Phase I/II GLORIA Trial with NOX-A12 in Brain Cancer Patients

NOXXON Pharma N.V. announced that the Data Safety Monitoring Board positively evaluated safety data from the initial four weeks of treatment of the first patient enrolled in the GLORIA clinical trial expansion arm.
[NOXXON Pharma N.V.]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

NOXXON Announces Enrollment of First Patient in the Expansion of the NOX-A12 Phase I/II Trial in Brain Cancer

NOXXON Pharma N.V. announced that the first patient was enrolled in an expansion arm of the GLORIA clinical trial of NOX-A12 in MGMT unmethylated brain cancer.
[NOXXON Pharma N.V.]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

How Brains Fold: USU Team Wins NIH Grant to Study Cerebral Shaping

Yu Huang, assistant professor of biological engineering, will receive $1.8 million from the National Institutes of Health to study cerebral morphology. Their goal is to better understand how a brain develops under spatial constraint and to uncover new insights into the spreading of brain cancer.
[Utah State University]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

CREB Signaling Activity Correlates with Differentiation and Survival in Medulloblastoma

Scientists observed that during normal cerebellar development, phosphorylated CREB was selectively expressed in differentiating cerebellar granule neuron progenitor (CGNP) cells.
[Scientific Reports]
[zotpress userid=” items=’PDWIU2IN’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Omniscient Neurotechnology Launches Quicktome Brain Mapping Platform for Neurosurgery after Regulatory Clearance in United States, Canada and Australia

Omniscient Neurotechnology, Inc. announced that it has received US FDA 510(k) clearance for Quicktome, a digital brain mapping platform that allows neurosurgeons to visualize and understand a patient’s brain networks prior to performing life-changing brain surgery.
[Omniscient Neurotechnology, Inc. (BusinessWire, Inc.)]
[zotpress userid=” items=’nan’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
[zotpress userid=’7753456′ items=’HIN6W5NH’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
[zotpress userid=” items=’LVPFR6Y2′ style=’apa’ cite=’yes’]
AbstractFull ArticlePress ReleaseGraphical Abstract
Bookmark

No account yet? Register

Share
Share