Omniscient Neurotechnology Launches Quicktome Brain Mapping Platform for Neurosurgery after Regulatory Clearance in United States, Canada and Australia

Omniscient Neurotechnology, Inc. announced that it has received US FDA 510(k) clearance for Quicktome, a digital brain mapping platform that allows neurosurgeons to visualize and understand a patient’s brain networks prior to performing life-changing brain surgery.
[Omniscient Neurotechnology, Inc. (BusinessWire, Inc.)]
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Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

Researchers showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
Shaim, H., Shanley, M., Basar, R., Daher, M., Gumin, J., Zamler, D. B., Uprety, N., Wang, F., Huang, Y., Gabrusiewicz, K., Miao, Q., Dou, J., Alsuliman, A., Kerbauy, L. N., Acharya, S., Mohanty, V., Mendt, M., Li, S., Lu, J., … Rezvani, K. (2021, June 17). Targeting the αv integrin-TGF-β axis improves natural killer cell function against glioblastoma stem cells. https://doi.org/10.1172/JCI142116 Cite
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Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
[Journal of Clinical Investigation]
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Brain Cancer Canada Funds Groundbreaking Glioblastoma Treatment Research

Brain Cancer Canada turns awareness into action by emphatically supporting groundbreaking research into brain cancer treatment. The charity has made $100,000 available to Dr. Sheila Singh and her research group at McMaster University to target recurrent Glioblastomas (GBMs) with generous support from sponsors, including Scotia Wealth Management, Yamana Gold, and Hampton Securities.
[Brain cancer Canada]
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NOXXON Announces Data Safety Monitoring Board Validates NOX-A12 Highest Dose in Phase 1/2 Brain Cancer Trial

NOXXON Pharma, Inc. announced that an independent Data Safety Monitoring Board has confirmed that the highest dose of NOX-A12 in combination with radiotherapy in the ongoing Phase I/II study in patients with brain cancer is safe and that the trial should continue as planned.
[NOXXON Pharma, Inc.]
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D&D Pharmatech Announces Sponsored Research Agreement with Yale University to Optimize Novel Strategies for the Treatment of Brain Cancer and Other Diseases of the Central Nervous System

D&D Pharmatech, Inc. announced it has entered into a sponsored research agreement with Yale University relating to optimization of two novel approaches that allow immune system cells and drug molecules to bypass the blood-brain barrier for the treatment of brain cancer and other disorders.
[D&D Pharmatech, Inc. (Business Wire, Inc.))]
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Rapid Reprogramming of Tumor Cells into Cancer Stem Cells on Double-Network Hydrogels

Researchers showed that a double-network hydrogel could rapidly reprogram differentiated cancer cells into cancer stem cells.
[Nature Biomedical Engineering]
Suzuka, J., Tsuda, M., Wang, L., Kohsaka, S., Kishida, K., Semba, S., Sugino, H., Aburatani, S., Frauenlob, M., Kurokawa, T., Kojima, S., Ueno, T., Ohmiya, Y., Mano, H., Yasuda, K., Gong, J. P., & Tanaka, S. (2021). Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels. Nature Biomedical Engineering, 1–12. https://doi.org/10.1038/s41551-021-00692-2 Cite
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P-Selectin Axis Plays a Key Role in Microglia Immunophenotype and Glioblastoma Progression

Scientists showed that P-selectin mediated microglia-enhanced glioblastoma proliferation and invasion by altering microglia/macrophages activation state.
[Nature Communications]
Yeini, E., Ofek, P., Pozzi, S., Albeck, N., Ben-Shushan, D., Tiram, G., Golan, S., Kleiner, R., Sheinin, R., Israeli Dangoor, S., Reich-Zeliger, S., Grossman, R., Ram, Z., Brem, H., Hyde, T. M., Magod, P., Friedmann-Morvinski, D., Madi, A., & Satchi-Fainaro, R. (2021). P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression. Nature Communications, 12(1), 1912. https://doi.org/10.1038/s41467-021-22186-0 Cite
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Autophagy Mediated Lipid Catabolism Facilitates Glioma Progression to Overcome Bioenergetic Crisis

Using glioma patient database and human glioma cells, scientists assessed the mechanisms and function of selective autophagy to sustain mTORC1 hyper-activation in glioma.
[British Journal of Cancer]
Wang, C., Haas, M. A., Yeo, S. K., Paul, R., Yang, F., Vallabhapurapu, S., Qi, X., Plas, D. R., & Guan, J.-L. (2021). Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-021-01294-0 Cite
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Pre-Clinical Investigation of Mesenchymal Stromal Cell-Derived Extracellular Vesicles

The authors classify and critically discuss the technical aspects of MSC-extracellular vesicle (EV) animal studies and discusses potential relationships between methodological details and the effectiveness of MSC-EVs as reported by these pre-clinical studies.
[Cytotherapy]

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SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation

The authors collate the most important discoveries relating to the neuroprotective effects of SOX1 in brain cancer and propose hypothesis worthy of SOX1’s role in the survival of senescent neuronal cells, its roles in fibroblast cell proliferation, and cell fate for neuroprotection, and the discharge of electrical impulses for homeostasis.
[Molecular Neurobiology]
Kanwore, K., Guo, X., Abdulrahman, A. A., Kambey, P. A., Nadeem, I., & Gao, D. (2021). SOX1 Is a Backup Gene for Brain Neurons and Glioma Stem Cell Protection and Proliferation. Molecular Neurobiology. https://doi.org/10.1007/s12035-020-02240-6 Cite
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