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brain cancer

Glioblastoma scRNAseq Shows Treatment-induced, Immune-dependent Rise In Mesenchymal Cancer Cells, and Structural Variants in Distal Neural Stem Cells

[Neuro-Oncology] Scientists used single-cell RNA-sequencing to analyze new and recurrent glioblastoma, and the nearby subventricular zone. They found four glioblastoma neural lineages were present in new and recurrent glioblastoma with an enrichment of the cancer mesenchymal lineage, immune cells, and reactive astrocytes in early recurrences.

3D Patient-Derived Tumor Models to Recapitulate Pediatric Brain Tumors In Vitro

[Translational Oncology] Scientists adapted a previously established brain tissue-model to fresh patient tumor cells with the goal of establishing 3D in vitro culture conditions for each tumor type.

Ivy Brain Tumor Center Opens New Clinical Trial for Patients with Recurrent Grade IV Gliomas

[The Ivy Brain Tumor Center] The Ivy Brain Tumor Center at Barrow Neurological Institute announced the opening of a new Phase 0/Ib clinical trial to evaluate AZD1390, an Ataxia telangiectasia mutant kinase inhibitor being developed by AstraZeneca, in patients with recurrent grade IV gliomas.

Regulation of Reverse Electron Transfer at Mitochondrial Complex I by Unconventional Notch Action in Cancer Stem Cells

[Developmental Cell] Researchers showed that reverse electron transfer through respiratory chain complex I was particularly active in brain cancer stem cells.

Chaperone-Mediated Autophagy Controls Proteomic and Transcriptomic Pathways to Maintain Glioma Stem Cell Activity

[Cancer Research] Investigators showed that LAMP2A expression was enriched in patient-derived glioblastoma stem cells (GSC), and its depletion diminished GSC-mediated tumorigenic activities.

Regulation of Reverse Electron Transfer at Mitochondrial Complex I by Unconventional Notch Action in Cancer Stem Cells

[Developmental Cell] The authors showed that reverse electron transfer through respiratory chain complex I was particularly active in brain CSCs.

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