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breast cancer cells

Analysis of the Estrogen Receptor-Associated lncRNA Landscape Identifies a Role for ERLC1 in Breast Cancer Progression

[Cancer Research] Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. Researchers cross-analyzed The Cancer Genome Atlas database and identified ERα-regulated long noncoding RNA 1 (ERLC1) as a long noncoding RNA exhibiting high specificity of expression in breast tissue.

Adipocyte-Derived Exosomes May Promote Breast Cancer Progression in Type 2 Diabetes

[Science Signaling] Researchers found that primary human adipocytes shed extracellular vesicles, specifically exosomes, that induced the expression of genes associated with epithelial-to-mesenchymal transition and cancer stem–like cell traits in cocultured breast cancer cell lines.

Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

[Journal of Experimental & Clinical Cancer Research] Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells-related therapies.

The Inhibition of Circular RNA circNOLC1 by Propofol/STAT3 Attenuates Breast Cancer Stem Cells Function via miR-365a-3p/STAT3 Signaling

[Journal of Translational Medicine] Scientists explored the function of circular RNA nucleolar and coiled-body phosphoprotein 1 (circNOLC1) in cancer stem cells of breast cancer and the inhibitory impact of propofol on circNOLC1.

Effects of Menopausal Hormone Therapy-Based on the Role of Estrogens, Progestogens, and Their Metabolites in Proliferation of Breast Cancer Cells

[Cancer Biology & Medicine] The authors describe the biological effects of estrogen, progesterone, and their metaboliteson the proliferation of breast cancer cells, based on relevant research and clinical trials, to improve our understanding of the biological functions of estrogen and progestogen and safety of menopausal hormone therapy.

3-D Vascularized Breast Cancer Model to Study the Role of Osteoblast in Formation of a Pre-Metastatic Niche

[Scientific Reports] Breast cancer cells preferentially metastasize to bone. To study the bone-tumor paracrine influence, a tri-cellular 3-D vascularized breast cancer tissue model was engineered which comprised MDA-MB231, TNBCs, fibroblasts, and endothelial cells.

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