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breast cancer cells

Interactions of BRCA1-Mutated Breast Cancer Cell Lines with Adipose-Derived Stromal Cells (ADSCs)

[Journal of Mammary Gland Biology and Neoplasia] Scientists investigated the interactions of BRCA1 mutated breast cancer cell lines with normal adipose-derived stromal cells. Interactions of conditioned medium of these cells with the breast cancer lines were studied using proliferation and migration assays as well as adipokine expression western blot arrays.

A Novel Long Non-Coding RNA AC073352.1 Promotes Metastasis and Angiogenesis via Interacting with YBX1 in Breast Cancer

[Cell Death & Disease] The authors identified a novel long non-coding RNA AC073352.1 that was significantly upregulated in breast cancer tissues and was associated with advanced TNM stages and poor prognosis in breast cancer patients.

Targeted Intracellular Delivery of Trastuzumab Using Designer Phage lambda Nanoparticles Alters Cellular Programs in Human Breast Cancer Cells

[ACS Nano] Trastuzumab-phage-like particles bound to the oncogenically active human epidermal growth factor receptor 2 (HER2) and were internalized by breast cancer cells of the HER2 overexpression subtype, but not by those lacking the HER2 amplification.

Inhibitors of PD-1/PD-L1 and ERK1/2 Impede the Proliferation of Receptor Positive and Triple-Negative Breast Cancer Cell Lines

[Journal of Cancer Research and Clinical Oncology] The effect of combined PD-1/PD-L1 and extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor treatment was investigated of cell growth and intracellular impact of breast cancer cell lines.

Serine Residues 726 and 780 Have Nonredundant Roles Regulating STAT5a Activity in Luminal Breast Cancer

[Scientific Reports] Phosphorylation of S726-, S780-, and Y694-STAT5a in response to prolactin in MCF7 luminal breast cancer cells was investigated with STAT5a knockdown and rescued with Y694F-, S726A-, or S780A-STAT5a, where the phospho-sites were mutated.

Breast Tumor Stiffness Instructs Bone Metastasis via Maintenance of Mechanical Conditioning

[Cell Reports] Fibrotic-like matrix stiffness promoted distinct metastatic phenotypes in breast cancer cells, which were preserved after transition to softer microenvironments, such as bone marrow.

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