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breast cancer stem cells

Targeting Prooxidant MnSOD Effect Inhibits Triple-Negative Breast Cancer (TNBC) Progression and M2 Macrophage Functions under the Oncogenic Stress

[Cell Death & Disease] Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.

O-linked α2,3 Sialylation Defines Stem Cell Populations in Breast Cancer

[Science Advances] Scientists identified a lectin, SLBR-N, which bound to O-linked α2,3 sialic acids, that was able to enrich for CSCs in vitro and in vivo. This O-glycan was expressed on CD44 and promoted its interaction with hyaluronic acid, facilitating CD44 signaling and CSC properties.

O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells

[Frontiers in Immunology] The stemness of OAcGD2+ cells isolated by sorting and the effects of mAb8B6 were assessed by cancer stem cell growth and mammosphere formation in vitro and tumor growth in vivo using patient-derived xenograft models.

Microfluidic Organ-on-Chip System for Multi-Analyte Monitoring of Metabolites in 3D Cell Cultures

[Lab On A Chip] Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.

Heterogeneity of BCSCs Contributes to the Metastatic Organotropism of Breast Cancer

[Journal of Experimental & Clinical Cancer Research] Scientists summarize current clinical trials, which assessed the safety and efficacy of breast cancer stem cells-related therapies.

Dual Cancer Stem Cell Manipulation to Enhance Phototherapy against Tumor Progression and Metastasis

[Journal of Controlled Release] Investigators engineered a photodynamic nanoplatform to manipulate breast cancer stem cells against tumor progression and metastasis by not only remolding the disequilibrium state but also blocking the epithelial-mesenchymal transition process.

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