breast cancer stem cells

[Proceedings of the National Academy of Sciences of the United States of America] Researchers demonstrated that calreticulin facilitated breast cancer progression by promoting the breast cancer stem cell phenotype through Wnt/β-catenin signaling in a hypoxia-inducible factor 1 (HIF-1)–dependent manner.

[Cell Reports] Investigators showed that hypoxia-inducible factor 1α (HIF-1α) is required for NANOG-mediated breast CSC enrichment.

[Molecular Cancer Research] To elucidate the underlying mechanisms that drive breast cancer stem cells (BCSCs) tumorigenicity in TNBC, scientists identified the long noncoding RNA BMP/OP-Responsive Gene (BORG) as an enhancer of BCSC phenotypes.

[Journal of Natural Medicines] The authors found that camalexin inhibited cell proliferation and migration of breast cancer cell lines. Camalexin also suppressed breast cancer stem cell-derived mammosphere formation.

[Journal of the American Chemical Society] Seven CADA compounds (CADA, VGD020, VGD071, TL020, TL023, LAL014, and DJ010) were examined for reduction of cellular sortilin expression and progranulin-induced breast cancer stem cell propagation.

[Journal of the American Chemical Society] The authors reported a small molecule construct, AzCDF, that allowed the therapeutic targeting of breast cancer stem cells and which was effective in normally refractory hypoxic tumor environments.