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breast cancer stem cells

Utilizing the Hippo Pathway as a Therapeutic Target for Combating Endocrine-Resistant Breast Cancer

[Cancer Cell International] Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.

PELP1/Src-3-Dependent Regulation of Metabolic Pfkfb Kinases Drives Therapy Resistant Er+ Breast Cancer

[Oncogene] Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.

Arginine Methyltransferase PRMT5 Methylates and Stabilizes KLF5 via Decreasing Its Phosphorylation and Ubiquitination to Promote Basal-Like Breast Cancer

[Cell Death & Differentiation] Protein arginine methyltransferase 5 (PRMT5) promoted breast cancer stem cell maintenance and proliferation, at least partially, by stabilizing krüppel-like factor 5 (KLF5).

Identification of Inhibitory Immune Checkpoints and Relevant Regulatory Pathways in Breast Cancer Stem Cells

[Cancer Medicine] Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast cancer stem cells, which were potentially regulated by Wnt, TGF‐β, and Hedgehog signaling.

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

[International Journal of Molecular Sciences] The authors discuss various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast cancer stem cells.

Signaling Pathways Governing Breast Cancer Stem Cells Behavior

[Stem Cell Research & Therapy] Scientists discuss known signaling mechanisms involved in the stimulation or prevention of breast cancer stem cells self-renewal, metastasis, and tumorigenesis.

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