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breast cancer

Circulating Tumor Cells at Baseline and Late Phase of Treatment Provide Prognostic Value in Breast Cancer

[Scientific Reports] To determine the prognostic value of the timing of circulating breast tumor cell measurement during treatment, peripheral blood from 164 patients with breast disease was collected.

Serine Residues 726 and 780 Have Nonredundant Roles Regulating STAT5a Activity in Luminal Breast Cancer

[Scientific Reports] Phosphorylation of S726-, S780-, and Y694-STAT5a in response to prolactin in MCF7 luminal breast cancer cells was investigated with STAT5a knockdown and rescued with Y694F-, S726A-, or S780A-STAT5a, where the phospho-sites were mutated.

Breast Tumor Stiffness Instructs Bone Metastasis via Maintenance of Mechanical Conditioning

[Cell Reports] Fibrotic-like matrix stiffness promoted distinct metastatic phenotypes in breast cancer cells, which were preserved after transition to softer microenvironments, such as bone marrow.

Polyphor Provides Update on the Phase III FORTRESS Study of Balixafortide in Patients with Advanced HER2 Negative Breast Cancer

[Polyphor AG] Polyphor AG announced that its global Phase III study, FORTRESS, evaluating balixafortide in combination with eribulin for the treatment of patients with HER2 negative, locally recurrent or metastatic breast cancer, did not meet its co-primary endpoint.

QAP14 Suppresses Breast Cancer Stemness and Metastasis via Activation of Dopamine D1 Receptor

[Acta Pharmacologica Sinica] Researchers found that QAP14 inhibited colony formation, cell motility, mammosphere formation and CSC frequency, induced CSC apoptosis and dopamine D1 receptor expression, and increased cAMP/cGMP levels.

Activated T Cell-Derived Exosomal PD-1 Attenuates PD-L1-Induced Immune Dysfunction in Triple-Negative Breast Cancer

[Oncogene] Despite its well-documented inhibitory effects, higher PD-1 expression in tumor-infiltrating lymphocytes was significantly associated with longer survival in triple-negative breast cancer patients.

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