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breast cancer

Mismatch Repair-Deficient Hormone Receptor-Positive Breast Cancers: Biology and Pathological Characterization

[Cancer Cell International] Researchers provide a comprehensive overview of the current state of knowledge of mismatch repair alterations in hormone receptor breast cancer.

Tumor-Derived Exosomal Components: The Multifaceted Roles and Mechanisms in Breast Cancer Metastasis

[Cell Death & Disease] The authors emphasize the multifaceted roles and mechanisms of tumor-derived exosomes in breast cancer metastasis, including the invasion behavior change, tumor vascularization, the disruption of the vascular barrier, and the colonization of the targeted organ.

Onconova Therapeutics Announces the Initial Dosing of the First Patient in the US Phase I Clinical Trial of ON 123300

[Onconova Therapeutics, Inc. (Globe Newswire, Inc.)] Onconova Therapeutics, Inc. announced that the first patient has been dosed in the US Phase I clinical trial of ON 123300, the company’s novel multi-kinase inhibitor, for HR+ HER 2- metastatic breast cancer patients who are refractory to, or progressing on, currently approved CDK 4/6 inhibitors.

Clarus Therapeutics and HavaH Therapeutics Announce Licensing Agreement for Product to Treat Androgen-Dependent Inflammatory Breast Disease and Certain Forms of Breast Cancer

[Clarus Therapeutics, Inc. (PR Newsire, Inc.)] Clarus Therapeutics, Inc. and HavaH Therapeutics announced a licensing agreement whereby Clarus will acquire the development and commercialization rights for CLAR-121. If approved, CLAR-121 would be the first T treatment of its kind for inflammatory breast disease, including estrogen receptor-positive breast cancer.

HDAC6 Inhibitors Sensitize Non-Mesenchymal Triple-Negative Breast Cancer Cells to Cysteine Deprivation

[Scientific Reports] To overcome cysteine deprivation resistance in TNBC cells, scientists identified three selective HDAC6 inhibitors using epigenetic compound library screening and used them to induce cell death in the non-mesenchymal TNBC.

OTUD7B Stabilizes Estrogen Receptor α and Promotes Breast Cancer Cell Proliferation

[Cell Death & Disease] The authors identified OTU domain-containing 7B (OTUD7B) as a bona fide deubiquitylase of ERα in breast cancer, revealing a post-translational mechanism between ERα and OTUD7B in ERα-positive breast cancer.

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