breast cancer

[EMBO Journal] Researchers discovered selective upregulation of HSP70-family chaperone HSPA1 and its co-factors, HSPH1 and DNAJB1, in MCF7 breast cancer cells acquiring thermotolerance.

[Nature Communications] Scientists found that PIK3CA-mutant ER+ breast cancers exhibited increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling.

[Cell Death & Disease] Investigators provided novel insights into the mechanisms of epidermal growth factor receptor-tyrosine kinase inhibitor resistance in TNBC via interaction of IL-26 with a newly identified receptor, and suggested IL-26 as a possible therapeutic target in TNBC.

[Cancer Letters] The authors found that the gamma-aminobutyric acid type A receptor π subunit (GABRP), as a membrane protein enriched in triple-negative breast cancer stem cells, interacted with epidermal growth factor receptor (EGFR) and significantly sustained its expression, resulting in stemness maintenance and chemotherapy resistance.

[npj Breast Cancer] Patients with high-risk DCIS were enrolled in this 3×3 Phase I dose-escalation pilot study of two, four and eight mg intralesional injections of the PD-1 immune checkpoint inhibitor, pembrolizumab.

[Proceedings of the National Academy of Sciences of the United States of America] Genetic silencing of MDA-9/Syntenin or treatment with a pharmacological inhibitor of the PDZ1 domain, PDZ1i, activated the immune system to kill cancer cells.