Tag results:
breast cancer
Mammary Cell News
Phytochemicals from Ajwa Dates Pulp Extract Induce Apoptosis in Human Triple-Negative Breast Cancer by Inhibiting AKT/mTOR Pathway and Modulating Bcl-2 Family Proteins
[Scientific Reports] Researchers analyzed the phytoconstituents in ethanolic Ajwa Dates Pulp Extract by liquid chromatography-mass spectrometry and investigated anticancer effects against MDA-MB-231 cells.
Mammary Cell News
Let-7f miRNA Regulates SDF-1α- and Hypoxia-Promoted Migration of Mesenchymal Stem Cells and Attenuates Mammary Tumor Growth upon Exosomal Release
[Cell Death & Disease] The authors examined intracellular levels of let-7f in 4T1 mammary carcinoma cells to test the hypothesis that let-7f released from human mesenchymal stem cells may be incorporated by tumor cells.
Mammary Cell News
Epithelial-Mesenchymal Transition Sensitizes Breast Cancer Cells to Cell Death via the Fungus-Derived Sesterterpenoid Ophiobolin A
[Scientific Reports] Using a model of experimentally induced epithelial-mesenchymal transition (EMT) in human mammary epithelial cells, researchers demonstrated that breast cancer cells enriched for EMT features were more sensitive to cytotoxicity induced by ophiobolin A.
Mammary Cell News
HER2-Positive Breast Cancer and Tyrosine Kinase Inhibitors: The Time Is Now
[npj Breast Cancer] The authors summarize currently approved tyrosine kinase inhibitors for HER2+ breast cancer, key clinical trials, and their use in current clinical practice.
Mammary Cell News
Exosomal microRNA-503-3p Derived from Macrophages Represses Glycolysis and Promotes Mitochondrial Oxidative Phosphorylation in Breast Cancer Cells by Elevating DACT2
[Cell Death Discovery] Scientists explored the impact of macrophage-derived exosomal miR-503-3p in the development of breast cancer by regulating disheveled-associated binding antagonist of beta-catenin 2 (DACT2).
Mammary Cell News
Mdivi-1 Induces Spindle Abnormalities and Augments Taxol Cytotoxicity in MDA-MB-231 Cells
[Cell Death Discovery] Researchers demonstrated that mdivi-1, a putative inhibitor of mitochondrial fission protein Drp1, enhanced the anticancer effects of taxol and overcame taxol resistance in a TNBC cell line.