Matrix Pore Size Governs Escape of Human Breast Cancer Cells from a Microtumor to an Empty Cavity

By varying the physical properties of collagen, investigators found that MDA-MB-231 tumor cells invaded and escaped faster in lower-density ECM. These effects were mediated by the ECM pore size, rather than by the elastic modulus or interstitial flow speed.
[iScience]
Tien, J., Ghani, U., Dance, Y. W., Seibel, A. J., Karakan, M. C., Ekinci, K. L., & Nelson, C. M. (2020). Matrix pore size governs escape of human breast cancer cells from a microtumor to an empty cavity. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101673 Cite
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Practical Classification of Triple-Negative Breast Cancer: Intratumoral Heterogeneity, Mechanisms of Drug Resistance, and Novel Therapies

Despite several efforts, transcriptomic and genomic classifications have remained merely theoretic and most of the patients are being treated with chemotherapy. Driver alterations in potentially targetable genes, including PIK3CA and AKT, have been identified across triple negative breast cancer subtypes, prompting the implementation of biomarker-driven therapeutic approaches.
[npj breast cancer]
Marra, A., Trapani, D., Viale, G., Criscitiello, C., & Curigliano, G. (2020). Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies. Npj Breast Cancer, 6(1), 1–16. https://doi.org/10.1038/s41523-020-00197-2 Cite
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Nanoparticle-Delivered Miriplatin Ultrasmall Dots Suppress Triple Negative Breast Cancer Lung Metastasis by Targeting Circulating Tumor Cells

Investigators found that active targeting nanoparticles displayed a superior DNA damage capability via enhanced-interactions with DNA and a significantly stronger effect in reducing cancer stem cell-like property of triple negative breast cancer cells, compared to conventional cisplatin and miriplatin.
[Journal of Controlled Release]
Li, Y., Qian, D., Lin, H.-P., Xie, J., Yang, P., Maddy, D., Xiao, Y., Huang, X., Wang, Z., & Yang, C. (2020). Nanoparticle-delivered miriplatin ultrasmall dots suppress triple negative breast cancer lung metastasis by targeting circulating tumor cells. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2020.10.015 Cite
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Pan-Cancer Analysis Reveals TAp63-Regulated Oncogenic lncRNAs that Promote Cancer Progression through AKT Activation

By performing a mouse-human cross species analysis between the TAp63 metastatic mammary adenocarcinoma mouse model and models of human breast cancer progression, researchers identified two TAp63-regulated oncogenic lncRNAs, TROLL-2 and TROLL-3.
[Nature Communications]
Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., Bedrosian, I., Mitsch, J., Quinlan, P., Thompson, A., Rajapakshe, K., Coarfa, C., Gunaratne, P. H., Marchion, D. C., Magliocco, A. M., Tsai, K. Y., & Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11(1), 5156. https://doi.org/10.1038/s41467-020-18973-w Cite
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Bispecific Antibodies for TNBC

The authors discuss novel bispecific antibodies for TNBC and emerging TNBC targets for future bispecific antibody development.
[Trends in Cancer]
Dees, S., Ganesan, R., Singh, S., & Grewal, I. S. (2020). Bispecific Antibodies for Triple Negative Breast Cancer. Trends in Cancer, 0(0). https://doi.org/10.1016/j.trecan.2020.09.004 Cite
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Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives

Investigators highlight various models of lymphatic metastasis, their potential pitfalls, and other tools available to study lymphatic metastasis including imaging modalities and -omic studies.
[Journal of Mammary Gland Biology and Neoplasia]
To, B., Isaac, D., & Andrechek, E. R. (2020). Studying Lymphatic Metastasis in Breast Cancer: Current Models, Strategies, and Clinical Perspectives. Journal of Mammary Gland Biology and Neoplasia. https://doi.org/10.1007/s10911-020-09460-5 Cite
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EZH2 Regulates Expression of FOXC1 by Mediating H3K27me3 in Breast Cancers

Scientists demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells.
[Acta Pharmacologica Sinica]
Zheng, X., Li, W., Yi, J., Liu, J., Ren, L., Zhu, X., Liu, S., Wang, J., & Du, G. (2020). EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-00543-x Cite
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OSR1 Phosphorylates the Smad2/3 Linker Region and Induces TGF-β1 Autocrine to Promote EMT and Metastasis in Breast Cancer

Interruption of the Oxidative stress-responsive kinase 1 (OSR1)-Smad2/3-TGF-β1 signaling axis elicited a robust anti-EMT and anti-metastatic effect in vitro and in vivo.
[Oncogene]
Li, Y., Li, L., Qin, J., Wu, J., Dai, X., & Xu, J. (2020). OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01499-2 Cite
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FBI-1 Enhanced the Resistance of Triple-Negative Breast Cancer Cells to Chemotherapeutic Agents via the miR-30c/PXR Axis

Factor that binds to the inducer of short transcripts‐1 (FBI-1) enhanced the resistance of TNBC cells to chemotherapeutic agents by repressing the expression of micoRNA-30c targeting the pregnane X receptor (PXR).
[Cell Death & Disease]
Yang, H., Ren, L., Wang, Y., Bi, X., Li, X., Wen, M., Zhang, Q., Yang, Y., Jia, Y., Li, Y., Zang, A., Wei, Y., & Dai, G. (2020). FBI-1 enhanced the resistance of triple-negative breast cancer cells to chemotherapeutic agents via the miR-30c/PXR axis. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03053-0 Cite
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Long Noncoding RNA FGF14-AS2 Inhibits Breast Cancer Metastasis by Regulating the miR-370-3p/FGF14 Axis

Investigators elucidated the potential role of a novel lncRNA FGF14-AS2 and the mechanisms underlying metastasis in breast cancer.
[Cell Death Discovery]
Jin, Y., Zhang, M., Duan, R., Yang, J., Yang, Y., Wang, J., Jiang, C., Yao, B., Li, L., Yuan, H., Zha, X., & Ma, C. (2020). Long noncoding RNA FGF14-AS2 inhibits breast cancer metastasis by regulating the miR-370-3p/FGF14 axis. Cell Death Discovery, 6(1), 1–14. https://doi.org/10.1038/s41420-020-00334-7 Cite
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Inhibition of O-GlcNAc Transferase Activates Tumor-Suppressor Gene Expression in Tamoxifen-Resistant Breast Cancer Cells

Researchers probed the importance of O-GlcNAc transferase activity for the survival of tamoxifen-sensitive and tamoxifen-resistant breast cancer cells.
[Scientific Reports]
Barkovskaya, A., Seip, K., Prasmickaite, L., Mills, I. G., Moestue, S. A., & Itkonen, H. M. (2020). Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Scientific Reports, 10(1), 16992. https://doi.org/10.1038/s41598-020-74083-z Cite
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