By deleting an essential autophagy gene or disrupting its autophagy function, investigators determined a mechanism of HER2+ breast cancer tumorigenesis by directly regulating the oncogenic driver.
[Developmental Cell]
Hao, M., Yeo, S. K., Turner, K., Harold, A., Yang, Y., Zhang, X., & Guan, J.-L. (2021). Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles. Developmental Cell, 0(0). https://doi.org/10.1016/j.devcel.2020.12.016 Cite
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