Reprogramming Lipid Metabolism Prevents Effector T Cell Senescence and Enhances Tumor Immunotherapy

Researchers report that development of T cell senescence driven by both malignant tumor cells and regulatory T cells is a general feature in cancers
[Science Translational Medicine]
Liu, X., Hartman, C. L., Li, L., Albert, C. J., Si, F., Gao, A., Huang, L., Zhao, Y., Lin, W., Hsueh, E. C., Shen, L., Shao, Q., Hoft, D. F., Ford, D. A., & Peng, G. (2021). Reprogramming lipid metabolism prevents effector T cell senescence and enhances tumor immunotherapy. Science Translational Medicine, 13(587). https://doi.org/10.1126/scitranslmed.aaz6314 Cite
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A Well Plate–Based Multiplexed Platform for Incorporation of Organoids into an Organ-on-a-Chip System with a Perfusable Vasculature

Investigators describe a detailed alternative method to cultivate millimeter-scale functional vascularized tissues on a biofabricated platform that enabled facile incorporation of organoid technology.
[Nature Protocols]
Lai, B. F. L., Lu, R. X. Z., Davenport Huyer, L., Kakinoki, S., Yazbeck, J., Wang, E. Y., Wu, Q., Zhang, B., & Radisic, M. (2021). A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nature Protocols, 1–32. https://doi.org/10.1038/s41596-020-00490-1 Cite
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Breast Cancer Dependence on MCL-1 Is Due to Its Canonical Anti-apoptotic Function

Scientists investigated the role of MCL-1 in clinically relevant breast cancer models and address whether the canonical role of MCL-1 in apoptosis, which can be targeted using BH3-mimetic drugs, is the major function for MCL-1 in breast cancer.
[Cell Death & Differentiation]
Campbell, K. J., Mason, S. M., Winder, M. L., Willemsen, R. B. E., Cloix, C., Lawson, H., Rooney, N., Dhayade, S., Sims, A. H., Blyth, K., & Tait, S. W. G. (2021). Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function. Cell Death & Differentiation, 1–12. https://doi.org/10.1038/s41418-021-00773-4 Cite
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Landscapes of Cellular Phenotypic Diversity in Breast Cancer Xenografts and Their Impact on Drug Response

A single-cell breast cancer mass cytometry panel was optimized to identify cell phenotypes and their oncogenic signaling states in a biobank of patient-derived tumour xenograft models representing the diversity of human breast cancer.
[Nature Communications]
Georgopoulou, D., Callari, M., Rueda, O. M., Shea, A., Martin, A., Giovannetti, A., Qosaj, F., Dariush, A., Chin, S.-F., Carnevalli, L. S., Provenzano, E., Greenwood, W., Lerda, G., Esmaeilishirazifard, E., O’Reilly, M., Serra, V., Bressan, D., Gordon B. Mills, Ali, H. R., … Caldas, C. (2021). Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response. Nature Communications, 12(1), 1998. https://doi.org/10.1038/s41467-021-22303-z Cite
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Differential Reprogramming of Breast Cancer Subtypes in 3D Cultures and Implications for Sensitivity to Targeted Therapy

Researchers systematically compared the transcriptomes of these different culture conditions by RNAseq of 14 breast cancer cell lines cultured in both 2D and 3D conditions.
[Scientific Reports]
Koedoot, E., Wolters, L., Smid, M., Stoilov, P., Burger, G. A., Herpers, B., Yan, K., Price, L. S., Martens, J. W. M., Le Dévédec, S. E., & van de Water, B. (2021). Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy. Scientific Reports, 11(1), 7259. https://doi.org/10.1038/s41598-021-86664-7 Cite
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Targeted Therapy to β3 Integrin Reduces Chemoresistance in Breast Cancer Bone Metastases

Researchers showed that β3 integrin induction by the bone microenvironment promotes resistance to chemotherapy through an altered metabolic response that can be defused by combination with αvβ3-targeted mTORC1 inhibitor nanotherapy.
[Molecular Cancer Therapeutics]
Fox, G. C., Su, X., Davis, J. L., Xu, Y., Kwakwa, K. A., Ross, M. H., Fontana, F., Xiang, J., Esser, A. K., Cordell, E., Pagliai, K., Dang, H. X., Sivapackiam, J., Stewart, S. A., Maher, C. A., Bakewell, S. J., Sharma, V., Achilefu, S., Veis, D. J., … Weilbaecher, K. N. (2021). Targeted therapy to β3 integrin reduces chemoresistance in breast cancer bone metastases. Molecular Cancer Therapeutics. https://doi.org/10.1158/1535-7163.MCT-20-0931 Cite
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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RANK Signaling Increases after Anti-HER2 Therapy Contributing to the Emergence of Resistance in HER2-Positive Breast Cancer

Scientists showed that RANK bound to HER2 in breast cancer cells and that enhanced RANK pathway activation altered HER2 phosphorylation status.
[Breast Cancer Research]
Sanz-Moreno, A., Palomeras, S., Pedersen, K., Morancho, B., Pascual, T., Galván, P., Benítez, S., Gomez-Miragaya, J., Ciscar, M., Jimenez, M., Pernas, S., Petit, A., Soler-Monsó, M. T., Viñas, G., Alsaleem, M., Rakha, E. A., Green, A. R., Santamaria, P. G., Mulder, C., … Gonzalez-Suarez, E. (2021). RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer. Breast Cancer Research, 23(1), 42. https://doi.org/10.1186/s13058-021-01390-2 Cite
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3D Bioprinting of Engineered Breast Cancer Constructs for Personalized and Targeted Cancer Therapy

The authors emphasized on the prospective future applications of 3D bioprinted cancer models for rapid and accurate drug screening in breast cancer.
[Journal of Controlled Release]
Sharifi, M., Bai, Q., Babadaei, M. M. N., Chowdhury, F., Hassan, M., Taghizadeh, A., Derakhshankhah, H., Khan, S., Hasan, A., & Falahati, M. (2021). 3D bioprinting of engineered breast cancer constructs for personalized and targeted cancer therapy. Journal of Controlled Release, 333, 91–106. https://doi.org/10.1016/j.jconrel.2021.03.026 Cite
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Generation of Two Induced Pluripotent Stem Cell Lines from Blood Cells of a Prostate Cancer Patient Carrying Germline Mutation in CHEK2

The authors generated two iPSC lines ZNHi001-A and ZNHi001-B from a prostate cancer patient carrying germline mutation in CHEK2 which might increase the risk of prostate cancer. Pluripotency and multi-lineage differentiation capacity of the two iPSC lines were confirmed by gene expression and teratoma assay.
[Stem Cell Research]
Liu, R., Qian, K., Xiao, Y., & Jiang, W. (2021). Generation of two induced pluripotent stem cell lines from blood cells of a prostate cancer patient carrying germline mutation in CHEK2. Stem Cell Research, 53, 102299. https://doi.org/10.1016/j.scr.2021.102299 Cite
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Anti-Estrogenic and Anti-Aromatase Activities of Citrus Peels Major Compounds in Breast Cancer

The authors investigated the antitumor potential of the most potent compounds in citrus peels on breast cancer by exploring their anti-estrogenic and anti-aromatase activities.
[Scientific Reports]
El-Kersh, D. M., Ezzat, S. M., Salama, M. M., Mahrous, E. A., Attia, Y. M., Ahmed, M. S., & Elmazar, M. M. (2021). Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Scientific Reports, 11(1), 7121. https://doi.org/10.1038/s41598-021-86599-z Cite
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