Inhibition of O-GlcNAc Transferase Activates Tumor-Suppressor Gene Expression in Tamoxifen-Resistant Breast Cancer Cells

Researchers probed the importance of O-GlcNAc transferase activity for the survival of tamoxifen-sensitive and tamoxifen-resistant breast cancer cells.
[Scientific Reports]
Barkovskaya, A., Seip, K., Prasmickaite, L., Mills, I. G., Moestue, S. A., & Itkonen, H. M. (2020). Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Scientific Reports, 10(1), 16992. https://doi.org/10.1038/s41598-020-74083-z Cite
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Inhibition of Chk1 by miR-320c Increases Oxaliplatin Responsiveness in Triple-Negative Breast Cancer

As checkpoint kinase 1 (Chk1) was associated with the DNA damage response (DDR), scientists investigated the effect of miR-320c on DDR in TNBC cells.
[Oncogenesis]
Inhibition of Chk1 by miR-320c increases oxaliplatin responsiveness in triple-negative breast cancer | Oncogenesis. (n.d.). Retrieved October 13, 2020, from https://www.nature.com/articles/s41389-020-00275-x Cite
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Targeting IL-3Rα on Tumor-Derived Endothelial Cells Blunts Metastatic Spread of Triple-Negative Breast Cancer via Extracellular Vesicle Reprogramming

Using human TNBC cell lines for in vitro studies, researchers found that, unlike native tumor–endothelial cells extracellular vesicles (EVs), anti-IL-3R-EVs increased apoptosis and reduced cell viability and migration.
[Oncogenesis]
Targeting IL-3Rα on tumor-derived endothelial cells blunts metastatic spread of triple-negative breast cancer via extracellular vesicle reprogramming | Oncogenesis. (n.d.). Retrieved October 13, 2020, from https://www.nature.com/articles/s41389-020-00274-y Cite
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The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Scientists used a knock-in mouse line, a genetic model for breast cancer and metastasis, a syngeneic melanoma lung colonization model, and orthotopic injection of E0771 breast cancer cells to show that alternative forms increased the diversity of Angiopoietin-2 function.
[Cancer Research]
Kapiainen, E., Kihlström, M. K., Pietilä, R., Kaakinen, M., Ronkainen, V.-P., Tu, H., Heikkinen, A., Devarajan, R., Miinalainen, I., Laitakari, A., Ansarizadeh, M., Zhang, Q., Wei, G.-H., Ruddock, L., Pihlajaniemi, T., Elamaa, H., & Eklund, L. (2020). The amino-terminal oligomerization domain of Angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-1904 Cite
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Jagged1-Notch1-Deployed Tumor Perivascular Niche Promotes Breast Cancer Stem Cell Phenotype through Zeb1

Scientists demonstrated that, with direct cell-cell contact, tumor microenvironment-derived endothelial cells provided the Notch ligand Jagged1 to neighboring breast cancer stem cells, leading to Notch1-dependent upregulation of Zeb1.
[Nature Communications]
Jiang, H., Zhou, C., Zhang, Z., Wang, Q., Wei, H., Shi, W., Li, J., Wang, Z., Ou, Y., Wang, W., Wang, H., Zhang, Q., Sun, W., Sun, P., & Yang, S. (2020). Jagged1-Notch1-deployed tumor perivascular niche promotes breast cancer stem cell phenotype through Zeb1. Nature Communications, 11(1), 5129. https://doi.org/10.1038/s41467-020-18860-4 Cite
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PRRG4 Promotes Breast Cancer Metastasis Through the Recruitment of NEDD4 and Downregulation of Robo1

Researchers uncovered that the transmembrane proline rich γ-carboxyglutamic acid protein 4 (PRRG4) promoted breast cancer metastasis by downregulating Robo1.
[Oncogene]
Zhang, L., Qin, Y., Wu, G., Wang, J., Cao, J., Wang, Y., Wu, D., Yang, K., Zhao, Z., He, L., Lyu, J., Li, H., & Gu, H. (2020). PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01494-7 Cite
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Mutant SF3B1 Promotes AKT and NF-kB Driven Mammary Tumorigenesis

Scientists identified that SF3B1 mutations in mammary epithelial and breast cancer cells induced a recurrent pattern of aberrant splicing leading to activation of AKT and NF-kB, enhanced cell migration, and accelerated tumorigenesis.
[Journal of Clinical Investigation]
Liu, B., Liu, Z., Chen, S., Ki, M., Erickson, C., Reis-Filho, J. S., Durham, B. H., Chang, Q., Stanchina, E. de, Sun, Y., Rabadan, R., Abdel-Wahab, O., & Chandarlapaty, S. (2020). Mutant SF3B1 promotes AKT and NF-kB driven mammary tumorigenesis. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI138315 Cite
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Determining the Efficiency of Single Molecule Quantum Dot Labeling of HER2 in Breast Cancer Cells

Investigators presented a strategy for determining the labeling efficiency of quantum dot labeling of HER2 in overexpressing breast cancer cells.
[Nano Letters]
Peckys, D. B., Quint, C., & Jonge, N. de. (2020). Determining the Efficiency of Single Molecule Quantum Dot Labeling of HER2 in Breast Cancer Cells. Nano Letters. https://doi.org/10.1021/acs.nanolett.0c02644 Cite
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Extracellular Matrix-Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer

Scientists uncovered that estrogen receptor-positive breast cancer cells cultured within extracellular matrix -scaffolds had an increase in ER signaling that occured via a MAPK-dependent, but estrogen-independent manner.
[Molecular Cancer Research]
DiGiacomo, J. W., Godet, I., Trautmann-Rodriguez, M., & Gilkes, D. M. (2020). Extracellular matrix-bound FGF2 mediates estrogen receptor signaling and therapeutic response in breast cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0554 Cite
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Athenex Oncology Launches Your Guide to Facing Metastatic Breast Cancer, a First-of-Its-Kind Self-Care Resource for People Living With Metastatic Breast Cancer

Athenex, Inc. announced that Athenex Oncology, a US based division of Athenex, launched Your Guide to Facing Metastatic Breast Cancer — a free, first-of-its-kind resource offering comprehensive lifestyle guidance to people living with metastatic breast cancer (MBC). The Guide provides evidence-based recommendations for increasing resilience, reducing stress, maintaining good dietary and sleep habits, managing inflammation, and other tips to improve quality of life while living with MBC.
[Athenex, Inc. (PR Newswire LLC)]
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Fibroblast-Derived IL-33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type-2 Immunity

Upregulation of IL-33 instigated type-2 inflammation in the metastatic microenvironment, and mediated recruitment of eosinophils, neutrophils and inflammatory monocytes to lung metastases.
[Cancer Research]
Shani, O., Vorobyov, T., Monteran, L., Lavie, D., Cohen, N., Raz, Y., Tsarfaty, G., Avivi, C., Barshack, I., & Erez, N. (2020). Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2116 Cite
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