A Review of Prognostic and Predictive Biomarkers in Breast Cancer

By combining established prognostic factors with valid prognostic/predicted biomarkers, scientists can start the journey to personalized treatment for every recently diagnosed breast cancer patient.
[Clinical and Experimental Medicine]
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Updates on Breast Biomarkers

The authors cover the evolution and latest updates of the CAP/ASCO guidelines relevant to these two important biomarkers in breast cancer.
[Virchows Archiv]
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Autophagy Inhibits Cancer Stemness in Triple-Negative Breast Cancer via miR-181a-Mediated Regulation of ATG5 and/or ATG2B

The authors identified that autophagy flux was inhibited in triple-negative breast cancer (TNBC) stem cells. miRNA-181a (miR-181a) expression is upregulated both in TNBC CSCs and patient tissues.
[Molecular Oncology]
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Low Glucose-Induced Overexpression of HOXC-AS3 Promotes Metabolic Reprogramming of Breast Cancer

Researchers revealed a critical role for HOXC-AS3 in regulating the metabolic reprogramming of breast cancer cells under metabolic stress.
[Cancer Research]
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STAT3 Induces Breast Cancer Growth via ANGPTL4, MMP13 and STC1 Secretion by Cancer Associated Fibroblasts

Researchers demonstrated that STAT3 was essential for the pro-tumorigenic functions of murine breast cancer cancer associated fibroblasts both in vitro and in vivo, and identified a STAT3 signature significantly enriched for genes encoding for secreted proteins.
[Oncogene]
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C/EBPβ Isoform-Specific Regulation of Migration and Invasion in Triple-Negative Breast Cancer Cells

Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.
[npj Breast Cancer]
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Comparative Transcriptional Analyses of Preclinical Models and Patient Samples Reveal MYC and RELA Driven Expression Patterns That Define the Molecular Landscape of IBC

The authors evaluated the transcriptome of an extended series of inflammatory breast cancer (IBC) preclinical models and performed a comparative analysis with patient samples to determine the extent to which the current models recapitulate the molecular characteristics of IBC observed clinically.
[npj Breast Cancer]
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Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors

Investigators analyzed lineage-dependent gene expression in human breast tumors to identify differences in metabolic gene expression that may limit pathway redundancy and create therapeutic vulnerabilities.
[Cell Reports]
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Rubius Therapeutics Announces Dosing of First Patient in Phase I/II Trial of RTX-224, a Broad Immune Agonist, for the Treatment of Certain Solid Tumors

Rubius Therapeutics, Inc. announced that the first patient has been dosed in its Phase I/II clinical trial of RTX-224 for the treatment of patients with certain relapsed/refractory or locally advanced solid tumors, including non-small cell lung cancer, cutaneous melanoma, head and neck squamous cell carcinoma, urothelia carcinoma and triple-negative breast cancer.
[Rubius Therapeutics, Inc.]
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MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

The authors demonstrated that MUC1-C drove global changes in chromatin architecture in the dedifferentiation of CRPC and triple-negative breast cancer cells.
[Molecular Cancer Research]
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Veru Announces FDA Grant of Fast Track Designation for Enobosarm for the Treatment of AR+ ER+ HER2- Metastatic Breast Cancer

Veru, Inc. announced that the US FDA has granted Fast Track designation to the Phase III registration program for the investigation of enobosarm for the treatment of androgen receptor positive, estrogen receptor positive, human epidermal growth factor receptor 2 negative (AR+ER+HER2-) metastatic breast cancer patients.
[Veru, Inc.]
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