breast cancer

[Cell Death & Disease] Scientists indicated that NONO enhanced nuclear epidermal growth factor receptor (EGFR)-mediated tumorigenesis and may be a potential therapeutic target for TNBC patients with nuclear EGFR expression.

[Nature Communications] Researchers demonstrated that a large subset of TNBC expressed significant levels of MAPK4, and this expression was critical for driving AKT activation independent of PI3K and promoting TNBC cell and xenograft growth.

[Cell Death & Disease] Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.

[Nature Communications] Scientists demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.

[npj Breast Cancer] Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor TNBC and prostate cancer.

[npj Breast Cancer] The authors characterized a population of stem-like breast cancer cells expressing the integrin αvβ3 as transcriptionally related to activated stem/basal cells in the normal human mammary gland.