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breast cancer

Circular RNA_0006014 Promotes Breast Cancer Progression through Sponging miR-885-3p to Regulate NTRK2 and PIK3/AKT Pathway

[Aging] qRT-PCR was used to detect the expression of circular RNA_0006014 (hsa_circ_0006014) and related genes. MTT, colony formation and Transwell assays were used to explore the potential biological functions of hsa_circ_0006014 in breast cancer cells.

JAC1 Targets YY1 Mediated JWA/p38 MAPK Signaling to Inhibit Proliferation and Induce Apoptosis in TNBC

[Cell Death Discovery] Researchers reported at the first time that JWA gene activating compound 1 (JAC1) inhibited the proliferation of TNBC in vitro and in vivo experimental models.

Tumor Suppressive Role of MicroRNA-4731-5p in Breast Cancer through Reduction of PAICS-Induced FAK Phosphorylation

[Cell Death Discovery] Breast cancer-related microRNA (miRNA) and messenger RNA microarray data sets were retrieved for differential analyses. Subsequently, the expression patterns of miR-4731-5p, PAICS, and FAK in breast cancer tissues and cells were determined.

FMNL2 Suppresses Cell Migration and Invasion of Breast Cancer: A Reduction of Cytoplasmic P27 via RhoA/LIMK/Cofilin Pathway

[Cell Death Discovery] Scientists investigated the effects of formin-like protein 2 (FMNL2) on breast cancer cell migration and invasion, and the underlying mechanisms involved.

CircRPAP2 Regulates the Alternative Splicing of PTK2 by Binding to SRSF1 in Breast Cancer

[Cell Death Discovery] The authors presented the first report that circular RNA RPAP2 (circRPAP2) was downregulated in breast cancer tissue samples and cell lines.

Influence of the Autotaxin-Lysophosphatidic Acid Axis on Cellular Function and Cytokine Expression in Different Breast Cancer Cell Lines

[Scientific Reports] Researchers analyzed in vitro the effect of lysophosphatidic acid (LPA)18:1 and the LPA receptor 1 (LPAR1), LPAR3, and LPAR2 inhibitor Ki16425 on cellular functions of different human breast cancer cell lines and the human breast epithelial cell line, as well as Interleukin 8, Interleukin 6 and tumor necrosis factor-alpha cytokine secretion after LPA-incubation.

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