breast cancer

[Scientific Reports] The authors found that a small molecule phenylbutenoid dimer NMac1, a previously identified anti-metastatic agent, had novel anti-proliferative effect only under glucose starvation in metastatic breast cancer cells.

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

[Cell Death & Disease] Scientists found that repression of the oncogenic transcription factor FOXM1 using FOXM1 shRNA or FOXM1 inhibitor FDI-6 could sensitize BRCA-proficient TNBC to PARP inhibitor Olaparib in vitro and in vivo.

[Dalton Transactions] For the development of anticancer drugs with higher activity and reduced toxicity, two approaches were combined: preparation of platinum complexes exhibiting higher stability compared to their platinum counterparts and loading them into mesoporous silica SBA-15.

[Molecular Cancer Research] Scientists observed that expression of a construct derived from the N-terminus of Stx4, which interfered with Stx4-Munc18c interaction, led to perturbed trafficking of MT1-MMP, and reduced invadopodium-based invasion in vitro, in models of TNBC.

[Cell Death Discovery] Non-coding RNAs including circular RNAs have been reported to be involved in different aspects during tumorigenesis and progression. Scientists explored the biological functions and underlying mechanism of circRPPH1 in breast cancer.