Investigators showed that Gal-GalNAc levels increased as human breast cancer progressed, and that occurrence of F. nucleatum gDNA in breast cancer samples correlated with high Gal-GalNAc levels.
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Scientists showed that Protein kinase C theta regulated the sensitivity of TNBC cells to apoptosis triggered by standard-of-care chemotherapy by regulating levels of pro-apoptotic Bim.
[Breast Cancer Research]
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Using the sleeping beauty transposon system in Brca1-deficient mice, researchers identified 169 putative cancer drivers, among which Notch1 was a top candidate for accelerating TNBC by promoting the epithelial-mesenchymal transition and regulating the cell cycle.
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The authors demonstrated that fibroblasts reduced lapatinib sensitivity in a subset of HER2+ breast cancer cells via paracrine signaling that could be reversed by targeting downstream survival programs such as MTOR and antiapoptotic proteins.
[Proceedings of the National Academy of Sciences of the United States of America]
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The authors introduced a novel “all-in-one nanosoldier” made of colloidal hybrid nanostructures, which were designed for simultaneously targeting, imaging, and killing TNBC cells. The results demonstrated that this novel strategy was highly effective for targeting and killing TNBC cells in vitro, expressing high levels of folate membrane-receptors.
[Journal of Materials Chemistry B]
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Scientists report new non-canonical regulatory properties of ultra-selective histone deacetylase inhibitors over the expression and function of epithelial-mesenchymal transition pathways and the invasiveness potential of breast cancer.
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Scientists presented an alternate method to culture individually selected cells in relative isolation from the rest of the population under physiologically relevant matrix conditions. Using examples of breast and colorectal cancers, scientists showed that individual cells evolve into tumors or aspects of tumors displaying different characteristics of the initial cancer type and aggressiveness.
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Investigators demonstrated that the histone binding function of Pygo2 was important for driving de-differentiation and malignancy of breast tumors, and loss of this binding activated various differentiation pathways which attenuated primary tumor growth and metastasis formation.
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Oncolytics Biotech® Inc announced a new investigator-sponsored triple-negative breast cancer study to be managed by Rutgers Cancer Institute of New Jersey. The phase II trial, known as IRENE, will investigate the use of pelareorep in combination with Incyte’s anti-PD-1 checkpoint inhibitor retifanlimab in patients with unresectable locally advanced or metastatic TNBC.
Researchers designed a mitochondrial targeted drug delivery system based on N-(2-hydroxypropyl) methacrylamide copolymers to simultaneously inhibit breast cancer progression and metastasis.
[Journal of Controlled Release]
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Researchers demonstrated that exposure to mechanical strain promoted invasive and pro-tumorigenic phenotypes in breast cancer cells, indicating that mechanical strain could impact the growth and proliferation of cancer cell, alter exosome production by breast cancer, and induce immunosuppression in the tumor microenvironment by dampening anti-tumor immunity.
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