breast cancer

[Cell Death & Disease] Investigators demonstrated that MLK4 promoted TNBC chemoresistance by regulating the pro-survival response to DNA-damaging therapies and identified a novel function of MLK4 in the regulation of DNA damage response signaling.

[Nature Communications] The authors examined 400 patient-derived breast epithelial and breast cancer explant cultures grown in various three-dimensional matrix scaffolds, and found that ERα was primarily regulated by the matrix stiffness.

[iScience] Researchers examined the significance of olfactory receptor (OR) transcript abundance in primary and metastatic breast cancer to the brain, bone, and lung. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells as well as metastasis to different organs.

[Developmental Cell] Researchers employed tamoxifen-inducible dual recombinase lineage tracing systems combined with live imaging and 5-cell RNA sequencing to track cancer cells undergoing partial or full epithelial-mesenchymal transition (EMT) in the MMTV-PyMT mouse model of metastatic breast cancer.

[Cell Death & Disease] Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes.

[Acta Pharmacologica Sinica] Investigators demonstrated that organic anion transporting polypeptide and endocytosis synergistically drove the uptake of the farnesylthiosalicylic acid-IR783 conjugate in breast cancer MDA-MB-231 cells, resulting in superior tumor-targeting ability of the conjugate both in vitro and in vivo.