breast cancer

[Nature Communications] Using breast cancer as a model of solid tumor metastasis to the bone marrow, we applied large-scale quantitative 3D imaging to characterize temporal changes in the bone marrow microenvironment during disease progression.

[Cell Reports] Researchers found that F-box and leucine-rich repeat protein 16 (FBXL16) acted as a tumor suppressor in TNBCs. FBXL16 directly bound to HIF1α and induced its ubiquitination and degradation, regardless of the tumor microenvironment, resulting in angiogenesis features of breast cancer.

[Bioengineered] Prostate cancer-associated transcript 18 (PCAT18) was expressed at low levels in TNBC, and PCAT18 could sponge miR-103a-3p and promote activating transcription factor 7 expression, resulting in prevention of TNBC metastasis.

[Oncogene] The authors showed that TMEM201, as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo.

[Cancer Research] Estrogen receptor alpha (ERα) plays a vital role in the development of normal breast tissue and in breast cancer. Researchers cross-analyzed The Cancer Genome Atlas database and identified ERα-regulated long noncoding RNA 1 (ERLC1) as a long noncoding RNA exhibiting high specificity of expression in breast tissue.

[Proteins-Structure Function and Bioinformatics] The authors evaluated the inhibitory activity of the chimeric protein against breast cancer cells in vitro and in vivo. They developed a novel multifunctional protein, consisting of p28, as a tumor-homing killer peptide fused to apoptin as a tumor-selective killer.