breast cancer

[Scientific Reports] Scientists targeted Monoacylglycerol lipase (MAGL) in TNBCs, using a potent carbamate-based inhibitor AM9928 with prolonged pharmacodynamic effects. AM9928 blocked TNBC cell adhesion and transmigration across human brain microvascular endothelial cells in 3D co-cultures.

[Scientific Reports] Researchers investigated the toxicity of different phosphate compounds to TNBCs, particularly, MDA-MB-231, and compared it to that of human monocytes, THP-1.

[Molecular Cancer] The authors investigated the expression profile of circular RNAs in breast cancer MCF-7 cells under hypoxia and normoxia using microarray.

[Genomics] Investigators elucidated an important role of PIEZO1 in breast cancer and provided key clues for identifying PIEZO1 as a therapeutic target and prognostic biomarker in breast cancer.

[Molecular Cancer Research] Scientists found that cancer-associated fibroblasts predominantly secreted hepatocyte growth factor (HGF) and activated MET receptor tyrosine kinase in TNBC cells.

[Molecular Cancer Research] Everolimus in combination with T-DM1 showed strong antitumor effects in HER2-positive breast cancer, both in vitro and in vivo.