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breast cancer

Agilent Receives FDA Companion Diagnostic Approval for Ki-67 IHC MIB-1 pharmDx in High-Risk Early Breast Cancer

[Agilent Technologies, Inc.] Agilent Technologies Inc announced its Ki-67 IHC MIB-1 pharmDx (Dako Omnis) is now FDA approved as an aid in identifying patients with early breast cancer at high risk of disease recurrence.

Fluid Flow Exposure Promotes Epithelial-to-Mesenchymal Transition and Adhesion of Breast Cancer Cells to Endothelial Cells

[Breast Cancer Research] Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.

Oestrogen Deprivation Induces Chemokine Production and Immune Cell Recruitment in In Vitro and In Vivo Models of Oestrogen Receptor-Positive Breast Cancer

[Breast Cancer Research] Scientists investigated the effect of oestrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.

Germline RAD51B Variants Confer Susceptibility to Breast and Ovarian Cancers Deficient in Homologous Recombination

[npj Breast Cancer] Investigators demonstrated that tumors harboring biallelic RAD51B alteration were deficient in homologous recombination DNA repair deficiency, as evidenced by analysis of sequencing data and in vitro functional assays.

A Novel Brain-Permeant Chemotherapeutic Agent for the Treatment of Brain Metastasis in Triple-Negative Breast Cancer

[Molecular Cancer therapeutics] Scientists investigated the activity of QBS10072S in vitro with various cell lines including the human TNBC cell line MDA-MB-231 and its brain-tropic derivative MDA-MB-231-BR3, where QBS10072S was found to be preferentially toxic to TNBC cells.

The Long Non-Coding RNA ET-20 Mediates EMT by Impairing Desmosomes in Breast Cancer Cells

[Journal of Cell Science] Researchers reported the identification of 114 novel long non-coding RNAs that changed their expression during TGFβ-induced epithelial-mesenchymal transition in murine breast cancer cells.

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