Oncogene PRR14 Promotes Breast Cancer through Activation of pI3K Signal Pathway and Inhibition of CHEK2 Pathway

Investigators showed PRR14 contributed to breast carcinogenesis mainly through overexpression, which derived from elevated transcription and gene amplification.
[Cell Death & Disease]
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Antitumor Effect of a WEE1 Inhibitor and Potentiation of Olaparib Sensitivity by DNA Damage Response Modulation in Triple-Negative Breast Cancer

Scientists investigated the antitumor effects of a WEE1 inhibitor and the mechanisms responsible for its effects on the cell cycle and DNA repair pathway as a monotherapy and in combination with a PARP inhibitor, an ATR inhibitor, and a DNA damage-inducing agent in six TNBC cell lines and in a Balb/c athymic nude mouse xenograft model.
[Scientific Reports]
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Mitochondrial Dysfunction Generates Aggregates That Resist Lysosomal Degradation in Human Breast Cancer Cells

Researchers demonstrated protein aggregates and autophagy receptors, TAX1BP1 and NDP52, as potential endpoints for monitoring autophagy during drug development and clinical studies.
[Cell Death & Disease]
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Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells

Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering]
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Verzenio® (abemaciclib) Significantly Reduced the Risk of Cancer Returning in People with High Risk HR+, HER2- Early Breast Cancer

Eli Lilly and Company announced Verzenio® in combination with standard adjuvant endocrine therapy has met the primary endpoint of invasive disease-free survival, significantly decreasing the risk of breast cancer recurrence or death compared to standard adjuvant endocrine therapy alone.
[Lilly]
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A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior

Investigators report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer.
[Nature Communications]
Schiano Lomoriello, I., Giangreco, G., Iavarone, C., Tordonato, C., Caldieri, G., Serio, G., Confalonieri, S., Freddi, S., Bianchi, F., Pirroni, S., Bertalot, G., Viale, G., Disalvatore, D., Tosoni, D., Malabarba, M. G., Disanza, A., Scita, G., Pece, S., Pilcher, B. K., … Di Fiore, P. P. (2020). A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior. Nature Communications, 11(1), 3020. https://doi.org/10.1038/s41467-020-16836-y Cite
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Caveolin-1 Inhibits Breast Cancer Stem Cells via c-Myc-Mediated Metabolic Reprogramming

Scientists demonstrated that the downregulation of caveolin-1 usually occurred in breast cancer stem cells and was associated with a metabolic switch from mitochondrial respiration to aerobic glycolysis.
[Cell Death & Disease]
Wang, S., Wang, N., Zheng, Y., Yang, B., Liu, P., Zhang, F., Li, M., Song, J., Chang, X., & Wang, Z. (2020). Caveolin-1 inhibits breast cancer stem cells via c-Myc-mediated metabolic reprogramming. Cell Death & Disease, 11(6), 1–16. https://doi.org/10.1038/s41419-020-2667-x Cite
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Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer

By immunohistochemistry scientists observed up-regulation of humanin in triple negative breast cancer biopsies when compared to mammary gland sections from healthy donors.
[Scientific Reports]
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Differential Functions of ERK1 and ERK2 in Lung Metastasis Processes in Triple-Negative Breast Cancer

Investigators provided evidence supporting the notion that ERK1 and ERK2 have functionally distinct properties and that ERK2, not ERK1, primarily contributed to lung metastasis in a riple negative breast cancer mouse model.
[Scientific Reports]
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Opposing Functions of BRD4 Isoforms in Breast Cancer

Investigators showed, by isoform-specific knockdown and endogenous protein detection, along with transgene expression, the less abundant bromodomain-containing protein 4 short isoform was oncogenic while bromodomain-containing protein 4 long isoform was tumor-suppressive in breast cancer cell proliferation and migration, as well as mammary tumor formation and metastasis.
[Molecular Cell]
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Destabilization of β-Catenin and RAS by Targeting the Wnt/β-Catenin Pathway as a Potential Treatment for Triple-Negative Breast Cancer

Scientists found that both β-catenin and RAS, as well as epidermal growth factor receptor, were overexpressed and correlated with one another in tumor tissues of TNBC patients.
[Experimental and Molecular Medicine]
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