breast cancer

[Molecular Therapy-Oncolytics] Researchers developed a plasmid-vector encoding for the secreted fusion protein sCV1-hIgG1, comprising of highly efficient CD47-blocking moiety CV1 and Fc domain of human IgG1 with maximized immune activation.

[Cell Death Discovery] Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.

[Cell Death Discovery] The authors showed that ERRFI1 was upregulated in sensitive hepatocellular carcinoma (HCC) cells, but not in resistant HCC cells, in response to tryptophan deficiency, and ERRFI1 expression level positively correlated with HCC patient overall survival.

[Bone Research] Scientists observed increased activation of pERK1/2 in osteolytic breast cancer cells and osteoblasts in human pathological specimens with aggressive osteolytic breast cancer metastases.

[Cancer Research] Mechanistically, ALDH1A1 decreased the intracellular pH in breast cancer cells to promote phosphorylation of TAK1, activated NFκB signaling, and increased the secretion of granulocyte macrophage colony-stimulating factor, which led to myeloid-derived suppressor cell expansion and immunosuppression.

[Cancer Immunology Research] Researchers demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function.