breast cancer

[Life Science Alliance] The authors sought to alter transcriptional programs by enforcing expression of the catalytic domain of the methylcytosine dioxygenase TET2 in breast cancer cells.

[Cell Cycle] On-target compounds specific to MCL-1 have demonstrated promising efficacy in preclinical models of breast cancer and show potential to enhance the anti-tumor effect of conventional therapies.

[Breast Cancer Research and Treatment] The authors highlight the unique characteristics of invasive lobular carcinoma (ILC) and describe the need for dedicated ILC clinical trials.

[Paige AI] Paige launched its latest product, Paige Breast Lymph Node, an AI medical device software that helps pathologists detect if breast cancer has metastasized to lymph nodes, concurrent with pathologists’ own interpretive review.

[Molecular Oncology] Whether TGFβ promoted stemness and invasiveness simultaneously via epithelial-mesenchymal transition remained unclear. They established a breast cancer cell model expressing red fluorescent protein under the E-cadherin promoter.

[Cell Death & Differentiation] The authors illustrated that HIF-2α, but not HIF-1α, induced stemness in breast cancer cells under hypoxia through SOD2-mtROS-PDI/GRP78-UPRER pathway, linking mitochondrial metabolic state to endoplasmic reticulum response via mitochondrial reactive oxygen species level.