FGFR4 Regulates Tumor Subtype Differentiation in Luminal Breast Cancer and Metastatic Disease

Scientists identified a subset of luminal A primary breast tumors to give rise to HER2-enriched subtype metastases, but remained clinically HER2 negative. By testing the unique genetic and transcriptomic features of these cases, they developed the hypothesis that FGFR4 likely participated in this subtype switching.
[Journal of Clinical investigation]
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Chronic Circadian Disruption Modulates Breast Cancer Stemness and Immune Microenvironment to Drive Metastasis in Mice

Investigators observed that circadian disruption significantly increased cancer-cell dissemination and lung metastasis. It also enhanced the stemness and tumor-initiating potential of tumor cells and created an immunosuppressive shift in the tumor microenvironment.
[Nature Communications]
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KLF4 Defines the Efficacy of the Epidermal Growth Factor Receptor Inhibitor, Erlotinib, in Triple-Negative Breast Cancer Cells by Repressing the EGFR gene

Investigators report that krüppel-like factor 4 was a major determinant of epidermal growth factor receptor expression and activity in TNBC cells.
[Breast Cancer Research]
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Contrasting DCIS and Invasive Breast Cancer by Subtype Suggests Basal-Like DCIS as Distinct Lesions

Investigators performed subtype stratified analyses and identified key differences between ductal carcinoma in situ and invasive breast cancer that suggested subtype specific progression.
[npj Breast Cancer]
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Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]
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Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells

Reasearchers showed that protein kinase C-ε promoted breast cancer cell survival not only by inhibiting apoptosis but also by inducing autophagy.
[International Journal of Molecular Sciences]
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Oncogene PRR14 Promotes Breast Cancer through Activation of pI3K Signal Pathway and Inhibition of CHEK2 Pathway

Investigators showed PRR14 contributed to breast carcinogenesis mainly through overexpression, which derived from elevated transcription and gene amplification.
[Cell Death & Disease]
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Antitumor Effect of a WEE1 Inhibitor and Potentiation of Olaparib Sensitivity by DNA Damage Response Modulation in Triple-Negative Breast Cancer

Scientists investigated the antitumor effects of a WEE1 inhibitor and the mechanisms responsible for its effects on the cell cycle and DNA repair pathway as a monotherapy and in combination with a PARP inhibitor, an ATR inhibitor, and a DNA damage-inducing agent in six TNBC cell lines and in a Balb/c athymic nude mouse xenograft model.
[Scientific Reports]
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Mitochondrial Dysfunction Generates Aggregates That Resist Lysosomal Degradation in Human Breast Cancer Cells

Researchers demonstrated protein aggregates and autophagy receptors, TAX1BP1 and NDP52, as potential endpoints for monitoring autophagy during drug development and clinical studies.
[Cell Death & Disease]
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Rapid Cancer Diagnosis and Early Prognosis of Metastatic Risk Based on Mechanical Invasiveness of Sampled Cells

Investigators evaluated the mechanical invasiveness of established breast and pancreatic cell lines and of tumor-cells from fresh, suspected pancreatic cancer tumors. The mechanical invasiveness matched the in vitro metastatic potential in cell lines as determined with Boyden chamber assays.
[Annals of Biomedical Engineering]
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Verzenio® (abemaciclib) Significantly Reduced the Risk of Cancer Returning in People with High Risk HR+, HER2- Early Breast Cancer

Eli Lilly and Company announced Verzenio® in combination with standard adjuvant endocrine therapy has met the primary endpoint of invasive disease-free survival, significantly decreasing the risk of breast cancer recurrence or death compared to standard adjuvant endocrine therapy alone.
[Lilly]
Press Release

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A Self-Sustaining Endocytic-Based Loop Promotes Breast Cancer Plasticity Leading to Aggressiveness and Pro-Metastatic Behavior

Investigators report that Epsin 3 is an oncogene with prognostic and therapeutic relevance in breast cancer.
[Nature Communications]
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