bronchial epithelial cells

[Nature Communications] Researchers observed that early Human rhinoviruses (HRV)-C15 infection induced a transitory barrier-protective metabolic state characterized by glycolysis that ultimately became exhausted as the infection progresses and led to cellular damage.

[Journal of Translational Medicine] Researchers used asthma model bronchial smooth muscle cells to measure the biological behaviors of Histone deacetylase 4 (HDAC4)-mediated Kruppel-like factor 5 (KLF5)/Slug/CXC chemokine ligand-12 (CXCL12) axis on the development of asthma in regulation of airway inflammation and remodeling.

[Molecular and Cellular Biochemistry] miR-1298-5p and suppressor of cytokine signaling 6 (SOCS6) were silenced or overexpressed in human bronchial epithelial cells. PKH-67 Dye was used to trace exosome endocytosis.

[Experimental and Molecular Medicine] Scientists evaluated the effect of neutrophil elastase on lipopolysaccharide - induced interleukin 8 production and determined the molecular mechanism in human bronchial epithelial cells.

[Science Immunology] To identify potent antiviral innate immune agonists, researchers screened a panel of 75 microbial ligands that activate diverse signaling pathways and identified cyclic dinucleotides, canonical STING agonists, as antiviral.

[Laboratory Investigation] Researchers investigated the molecular mechanism of enhancer of zeste homolog 2 (EZH2) in the development of asthma.