Cancer Stem Cell News

[Embo Journal] Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.

[Journal of Immunology] lncRNA interactome, RNA immunoprecipitation, and coimmunoprecipitation studies identified BCR-mediated Ca+ signaling (BCALM)-interacting proteins in B cells, including phospholipase D 1, and kinase adaptor proteins AKAP9 and AKAP13.

[Arthritis Research & Therapy] The authors identified the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome at the transcriptome level.

[Leukemia] Main challenges to CAR-T cell therapy will be highlighted as well as strategies to structurally improve the CAR-T cell product, and thereby its efficacy and safety.

[Frontiers in Immunology] Researchers showed that circulating tumor cells isolated from immunotherapy-resistant metastatic melanoma patients expressed higher levels of nuclear lysine specific demethylase 1 (LSD1) phosphorylated at serine 111 compared to responders, which is associated with co-expression of stem-like, mesenchymal genes.