Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells

Scientists attempted to clarify whether apigenin could improve the antitumor efficiency of cisplatin in lung cancer using cancer stem cells.
[Nutrition and Cancer-An International Journal]
Li, Y., Chen, X., He, W., Xia, S., Jiang, X., Li, X., Bai, J., Li, N., Chen, L., & Yang, B. (2020). Apigenin Enhanced Antitumor Effect of Cisplatin in Lung Cancer via Inhibition of Cancer Stem Cells. Nutrition and Cancer, 0(0), 1–9. https://doi.org/10.1080/01635581.2020.1802494 Cite
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Tonicity-Responsive Enhancer-Binding Protein Promotes Stemness of Liver Cancer and Cisplatin Resistance

Tonicity-responsive enhancer binding protein (TonEBP) was required for the tumorigenesis and self-renewal of liver CSCs. Cisplatin induced the recruitment of the ERCC1/XPF dimer to the chromatin in a TonEBP-dependent manner leading to DNA repair and cisplatin resistance.
[Ebiomedicine]
Lee, J. H., Suh, J. H., Kang, H. J., Choi, S. Y., Jung, S. W., Lee-Kwon, W., Park, S.-A., Kim, H., Ye, B. J., Yoo, E. J., Jeong, G. W., Park, N. H., & Kwon, H. M. (2020). Tonicity-responsive enhancer-binding protein promotes stemness of liver cancer and cisplatin resistance. EBioMedicine, 58. https://doi.org/10.1016/j.ebiom.2020.102926 Cite
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AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

Scientists showed that AU-rich element RNA-binding protein 1 was an important inducer of the epithelial-to-mesenchymal transition process through stabilization of SNAIL1 and TWIST1 and the consequent promotion of breast cancer stem cells.
[Oncogenesis]
AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 | Oncogenesis. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41389-020-00255-1 Cite
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

Researchers summarized recent literature regarding molecules and pathways and reviewed the effects of cancer stem cells biology during the formation of brain metastasis in TNBC.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
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Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
Tadano, H., Tsukahara, T., Mizushima, E., Akamatsu, A., Watanabe, K., Nojima, I., Kubo, T., Kanaseki, T., Hirohashi, Y., Sato, N., & Torigoe, T. (2020). Development of an artificial antibody specific for HLA/peptide complex derived from cancer stem-like cell/cancer-initiating cell antigen DNAJB8. British Journal of Cancer, 1–8. https://doi.org/10.1038/s41416-020-1017-1 Cite
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
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AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

Researchers showed that AUF1 induced epithelial-to-mesenchymal transition and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation.
[Oncogenesis]
AlAhmari, M. M., Al-Khalaf, H. H., Al-Mohanna, F. H., Ghebeh, H., & Aboussekhra, A. (2020). AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1. Oncogenesis, 9(8), 1–12. https://doi.org/10.1038/s41389-020-00255-1 Cite
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DOCK6 Promotes Chemo- and Radioresistance of Gastric Cancer by Modulating WNT/β-Catenin Signaling and Cancer Stem Cell Traits

The authors identified DOCK6, a guanine nucleotide exchange factor for Rac1 and CDC42, as an independent biomarker for gastric cancer prognosis. Clinical findings indicate the positive correlation of higher DOCK6 expression with tumor size, depth of invasion, lymph node metastasis, vascular invasion, and pathological stage.
[Oncogene]
Chi, H.-C., Tsai, C.-Y., Wang, C.-S., Yang, H.-Y., Lo, C.-H., Wang, W.-J., Lee, K.-F., Lai, L.-Y., Hong, J.-H., Chang, Y.-F., Tsai, M.-M., Yeh, C.-T., Wu, C. H., Hsieh, C.-C., Wang, L.-H., Chen, W.-J., & Lin, K.-H. (2020). DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01390-0 Cite
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Continuous Formation of Small Clusters with LGR5-Positive Cells Contributes to Tumor Growth in a Colorectal Cancer Xenograft Model

Investigators evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which was a cancer stem cell marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally.
[Laboratory Investigation]
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Regulating Stem Cell-Related Genes Induces the Plastic Differentiation of Cancer Stem Cells to Treat Breast Cancer

Investigators propose a plastic differentiation strategy for irreversible differentiation of cancer stem cells, and salinomycin and its newly constructed functional liposomes were used to implement this strategy.
[Molecular Therapy-Oncolytics]
Zhang, J.-Y., Luo, Q., Xu, J.-R., Bai, J., Mu, L.-M., Yan, Y., Duan, J.-L., Cui, Y.-N., Su, Z.-B., Xie, Y., & Lu, W.-L. (2020). Regulating stem cell-related genes induces the plastic differentiation of cancer stem cells to treat breast cancer. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.07.009 Cite
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Histamine H4 Receptor Agonists Induce Epithelial-Mesenchymal Transition Events and Enhance Mammosphere Formation via Src and Tgf-β Signaling in Breast Cancer Cells

This study investigated the effects of H4R ligands on epithelial-mesenchymal transition and mammosphere formation as a surrogate assay for cancer stem cells in breast cancer cells with different invasive phenotype. They also investigated the participation of Src and TGF-β signaling in these events.
[Biochemical Pharmacology]
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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
[Cell Stem Cell]
Cheung, P., Xiol, J., Dill, M. T., Yuan, W.-C., Panero, R., Roper, J., Osorio, F. G., Maglic, D., Li, Q., Gurung, B., Calogero, R. A., Yilmaz, Ö. H., Mao, J., & Camargo, F. D. (2020). Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.003 Cite
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