cancer stem cells

[Cancer Medicine] Investigators analyzed the role of MSCs in the tumor microenvironment and summarized the relationship between MSCs and liver cancer stem cells.

[Scientific Reports] Researchers investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for one to seven days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed by RT-qPCR, Western blotting and flow cytometry together with Wright-Giemsa staining and immunocytochemistry.

[Journal of Pathology] Researchers reported that the enzyme Euchromatic Histone Lysine Methyltransferase 1 (EHMT1) was expressed in primary and relapsed Alveolar Rhabdomyosarcoma tumors.

[Translational Oncology] Investigators found that overexpression of Rec8 meiotic recombination protein (Rec8) facilitated the migration and invasion of colorectal cancer cells (CRC) in vitro and promoted the liver metastasis of CRC in vivo.

[Journal of Cellular Biochemistry] Scientists summarize the current understanding of the regulatory mechanisms of T-box genes in cancer, epithelial-mesenchymal transition, and CSCs, and discuss the implications of targeting T-box genes as anticancer therapeutics.

[Oncology Let] Scientists elucidated the role of ZNF750 in the inhibition of the renewal ability of CSCs derived from the oral squamous cell carcinoma cell line, CAL‑27.