cancer stem cells

[Aging] Scientists explored the efficacy of anemoside B4 (AB4) in 5-Fluorouracil (FU)-based chemotherapy in colorectal cancer cells and the underlying molecular mechanisms. They indicated a significant synergistic activity of AB4 in 5-FU treated colorectal cancer cells

[Food Chemistry] Scientists evaluated the in vitro effect of Manuka honey and its combination with 5-Fu, the most common drug used in the treatment of colon cancer, on the morphological and physical parameters of colonspheres enriched with cancer stem-like cells deriving from HCT-116 colon adenocarcinoma cell line and on the apoptosis rate.

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

[Small] A self-assembled heterodimer consisting of clustered regularly interspaced short palindromic repeats/Cas12a linkage was designed for in situ identification and screening of gastric CSCs from gastric cancer cells.

[Chemical Communications] Researchers introduced a prodrug consisting of 1,3-oxathiolane as an ROS responsive scaffold, and an aldehyde protecting group of DEAB to deliver the co-treatment of anti-cancer drug and ALDH inhibitor upon reaction with ROS.

[Environmental Toxicology] Researchers found that RNF168 expression was positively correlated with the overall survival, first-progression survival, and postprogression survival of lung adenocarcinoma, but not correlated with these survivals of squamous cell carcinoma of lung.